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- W1945271035 endingPage "394" @default.
- W1945271035 startingPage "383" @default.
- W1945271035 abstract "Notch2 and Notch3 and genes of the Notch signaling network are dynamically expressed in developing follicles, where they are essential for granulosa cell proliferation and meiotic maturation. Notch receptors, ligands, and downstream effector genes are also expressed in testicular Leydig cells, predicting a potential role in regulating steroidogenesis. In this study, we sought to determine if Notch signaling in small follicles regulates the proliferation response of granulosa cells to FSH and represses the up-regulation steroidogenic gene expression that occurs in response to FSH as the follicle grows. Inhibition of Notch signaling in small preantral follicles led to the up-regulation of the expression of genes in the steroid biosynthetic pathway. Similarly, progesterone secretion by MA-10 Leydig cells was significantly inhibited by constitutively active Notch. Together, these data indicated that Notch signaling inhibits steroidogenesis. GATA4 has been shown to be a positive regulator of steroidogenic genes, including STAR protein, P450 aromatase, and 3B-hydroxysteroid dehydrogenase. We observed that Notch downstream effectors HEY1, HEY2, and HEYL are able to differentially regulate these GATA4-dependent promoters. These data are supported by the presence of HEY/HES binding sites in these promoters. These studies indicate that Notch signaling has a role in the complex regulation of the steroidogenic pathway." @default.
- W1945271035 created "2016-06-24" @default.
- W1945271035 creator A5007954392 @default.
- W1945271035 creator A5038634586 @default.
- W1945271035 creator A5053052315 @default.
- W1945271035 creator A5060062447 @default.
- W1945271035 creator A5090125870 @default.
- W1945271035 date "2015-10-01" @default.
- W1945271035 modified "2023-10-14" @default.
- W1945271035 title "Notch signaling represses GATA4-induced expression of genes involved in steroid biosynthesis" @default.
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