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- W1945288563 abstract "In an open study, 21 patients suffering from chronic non-seasonal rhinitis and allergic to house mites (HDM) have been treated for 1 year with either a new extract (Pharmalgen; n= 10) or an allergoid, pyridine denatured, extract (Alavac; n= 11), both precipitated with AlOH3, (depot). The following investigations were performed before and after therapy: clinical scoring (for 4 weeks), quantified skin prick tests (SPT) and nasal provocation tests (NPT) with HDM, and determination in serum of HDM-specific IgE and IgG. Both groups were compared with six patients who remained untreated and underwent the same investigations. Hyposensitization with either extract induced an improvement in clinical scores (P < 0.05), a decrease in SPT reactivity (Pharmalgen: P < 0.001; Alavac: P < 0.01), a marked increase in the nasal tolerance to HDM (P < 0.001) and in HDM-specific IgG (P < 0.001). In the group of untreated patients, all these parameters remained unchanged. Compared with the Alavac extract, the Pharmalgen extract was more active in decreasing SPT reactions (P < 0.05) and inducing a HDM-specific IgG rise (P < 0.05). Although both extracts induced some untoward allergic reactions, no adrenaline was used at any time during the study. These data suggest that hyposensitization with depot extracts of HDM can be considered a safe and active adjunct to the treatment of allergic rhinitis." @default.
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- W1945288563 date "1990-07-01" @default.
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- W1945288563 title "Effects of one-year hyposensitization in allergic rhinitis." @default.
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- W1945288563 doi "https://doi.org/10.1111/j.1398-9995.1990.tb00516.x" @default.
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