FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1945463512> ?p ?o ?g. }

• W1945463512 endingPage "317" @default.
• W1945463512 startingPage "291" @default.
• W1945463512 abstract "Most forms of Alzheimer’s disease (AD) are sporadic (sAD) or inherited in a non-Mendelian fashion, and less than 1% of cases are autosomal-dominant. Forms of sAD do not exhibit familial aggregation and are characterized by complex genetic and environmental interactions. Recently, the expansion of g enomic methodologies, in association with substantially larger combined cohorts, has resulted in various genome-wide association studies that have identified several novel genetic associations of AD. Currently, the most effective methods for establishing the diagnosis of AD are defined by multi-modal pathways, starting with clinical and neuropsychological assessment, cerebrospinal fluid (CSF) analysis, and brain-imaging procedures, all of which have significant cost- and access-to-care barriers. Consequently, research efforts have focused on the development and validation of non-invasive and generalizable blood-based biomarkers. Among the modalities conceptualized by the systems biology paradigm and utilized in the “exploratory biomarker discovery arena”, proteome analysis has received the most attention. However, metabolomics, lipidomics, transcriptomics, and epigenomics have recently become key modalities in the search for AD biomarkers. Interestingly, biomarker changes for familial AD (fAD), in many but not all cases, seem similar to those for sAD. The integration of neurogenetics with systems biology/physiology-based strategies and high-throughput technologies for molecular profiling is expected to help identify the causes, mechanisms, and biomarkers associated with the various forms of AD. Moreover, in order to hypothesize the dynamic trajectories of biomarkers through disease stages and elucidate the mechanisms of biomarker alterations, updated and more sophisticated theoretical models have been proposed for both sAD and fAD." @default.
• W1945463512 created "2016-06-24" @default.
• W1945463512 creator A5036518738 @default.
• W1945463512 creator A5037109052 @default.
• W1945463512 creator A5059630674 @default.
• W1945463512 creator A5068394264 @default.
• W1945463512 creator A5069514442 @default.
• W1945463512 creator A5075804608 @default.
• W1945463512 creator A5091785793 @default.
• W1945463512 date "2015-07-24" @default.
• W1945463512 modified "2023-09-30" @default.
• W1945463512 title "Biomarkers in Sporadic and Familial Alzheimer’s Disease" @default.
• W1945463512 cites W1485243151 @default.
• W1945463512 cites W1557259094 @default.
• W1945463512 cites W1568609804 @default.
• W1945463512 cites W1602771322 @default.
• W1945463512 cites W1746708220 @default.
• W1945463512 cites W1889314685 @default.
• W1945463512 cites W1916193671 @default.
• W1945463512 cites W1919825598 @default.
• W1945463512 cites W1937509560 @default.
• W1945463512 cites W1964049915 @default.
• W1945463512 cites W1964464904 @default.
• W1945463512 cites W1964869332 @default.
• W1945463512 cites W1965327593 @default.
• W1945463512 cites W1965406612 @default.
• W1945463512 cites W1966378897 @default.
• W1945463512 cites W1966720891 @default.
• W1945463512 cites W1966831629 @default.
• W1945463512 cites W1967229678 @default.
• W1945463512 cites W1968790254 @default.
• W1945463512 cites W1968940781 @default.
• W1945463512 cites W1969387743 @default.
• W1945463512 cites W1972025839 @default.
• W1945463512 cites W1974034152 @default.
• W1945463512 cites W1974874396 @default.
• W1945463512 cites W1976115853 @default.
• W1945463512 cites W1977184198 @default.
• W1945463512 cites W1979078721 @default.
• W1945463512 cites W1979631864 @default.
• W1945463512 cites W1980613776 @default.
• W1945463512 cites W1980636621 @default.
• W1945463512 cites W1981458288 @default.
• W1945463512 cites W1981554609 @default.
• W1945463512 cites W1981686145 @default.
• W1945463512 cites W1985058290 @default.
• W1945463512 cites W1985113736 @default.
• W1945463512 cites W1988332799 @default.
• W1945463512 cites W1990143520 @default.
• W1945463512 cites W1990502495 @default.
• W1945463512 cites W1993571512 @default.
• W1945463512 cites W1994580857 @default.
• W1945463512 cites W1996317447 @default.
• W1945463512 cites W1997457117 @default.
• W1945463512 cites W1999543741 @default.
• W1945463512 cites W1999639760 @default.
• W1945463512 cites W2000397440 @default.
• W1945463512 cites W2000448487 @default.
• W1945463512 cites W2001032146 @default.
• W1945463512 cites W2001690023 @default.
• W1945463512 cites W2004937032 @default.
• W1945463512 cites W2006325146 @default.
• W1945463512 cites W2006858320 @default.
• W1945463512 cites W2007466714 @default.
• W1945463512 cites W2008917014 @default.
• W1945463512 cites W2010418703 @default.
• W1945463512 cites W2013391120 @default.
• W1945463512 cites W2015490916 @default.
• W1945463512 cites W2015759485 @default.
• W1945463512 cites W2015876677 @default.
• W1945463512 cites W2017260345 @default.
• W1945463512 cites W2017779103 @default.
• W1945463512 cites W2017865966 @default.
• W1945463512 cites W2018724570 @default.
• W1945463512 cites W2019082497 @default.
• W1945463512 cites W2019564007 @default.
• W1945463512 cites W2020706970 @default.
• W1945463512 cites W2021181758 @default.
• W1945463512 cites W2023121717 @default.
• W1945463512 cites W2023646148 @default.
• W1945463512 cites W2025594724 @default.
• W1945463512 cites W2028846933 @default.
• W1945463512 cites W2028989537 @default.
• W1945463512 cites W2030600654 @default.
• W1945463512 cites W2030827315 @default.
• W1945463512 cites W2031467869 @default.
• W1945463512 cites W2032828176 @default.
• W1945463512 cites W2033111895 @default.
• W1945463512 cites W2033468757 @default.
• W1945463512 cites W2034286717 @default.
• W1945463512 cites W2034968148 @default.
• W1945463512 cites W2039135009 @default.
• W1945463512 cites W2039892005 @default.
• W1945463512 cites W2040880523 @default.
• W1945463512 cites W2041741792 @default.
• W1945463512 cites W2042466570 @default.
• W1945463512 cites W2043358664 @default.
• W1945463512 cites W2044365168 @default.

• next