Matches in SemOpenAlex for { <https://semopenalex.org/work/W1945499848> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1945499848 endingPage "12" @default.
- W1945499848 startingPage "807" @default.
- W1945499848 abstract "KR-30450 (2-(2(1,3-dioxolone)-2-methyl-4-(2'-oxo-1'-pyrrollidinyl) -6- nitro-2H-1-benzopyren) is a newly synthesized benzopyran derivative. We examined the effect of KR-30450 on the action potential duration of isolated rat papillary muscle and on the ATP-sensitive K+ channel (KATP) activity in single rat ventricular myocytes with 3 M KCl-filled conventional microelectrode and patch clamp techniques. KR-30450 (10(-7) approximately 10(-5) M) reduced the action potential duration in a concentration-dependent manner and this was inhibited by 3 microM glibenclamide, suggesting that KATP was involved. In cell-attached patches, KR-30450 (10(-5) M) in the pipette activated the KATP which was closed by 3 microM glibenclamide. In inside-out patches, the effects of KR-30450 on KATP activity were examined before and after run-down of the channel. Before run-down, KR-30450 increased the KATP activity only in the presence of ATP and shifted the [ATP]i-KATP activity relationship to the right. After run-down, KR-30450 did not affect the KATP activity either in the presence or absence of 3 mM UDP, but increased the UDP-induced KATP activity in the presence of 1 mM ATP-gamma-S. From these results, we conclude that KR-30450 antagonizes the inhibitory effect of ATP on the KATP in a competitive manner. These effects of KR-30450 are similar to those of ER-001533 and HOE-234, but different from those of pinacidil and lemakalim." @default.
- W1945499848 created "2016-06-24" @default.
- W1945499848 creator A5001217563 @default.
- W1945499848 creator A5003925513 @default.
- W1945499848 creator A5007678700 @default.
- W1945499848 creator A5014037760 @default.
- W1945499848 creator A5021201795 @default.
- W1945499848 creator A5035038487 @default.
- W1945499848 creator A5063582061 @default.
- W1945499848 creator A5072020215 @default.
- W1945499848 date "1995-11-01" @default.
- W1945499848 modified "2023-09-23" @default.
- W1945499848 title "KR-30450, a newly synthesized benzopyran derivative, activates the cardiac ATP-sensitive K+ channel." @default.
- W1945499848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7473170" @default.
- W1945499848 hasPublicationYear "1995" @default.
- W1945499848 type Work @default.
- W1945499848 sameAs 1945499848 @default.
- W1945499848 citedByCount "6" @default.
- W1945499848 crossrefType "journal-article" @default.
- W1945499848 hasAuthorship W1945499848A5001217563 @default.
- W1945499848 hasAuthorship W1945499848A5003925513 @default.
- W1945499848 hasAuthorship W1945499848A5007678700 @default.
- W1945499848 hasAuthorship W1945499848A5014037760 @default.
- W1945499848 hasAuthorship W1945499848A5021201795 @default.
- W1945499848 hasAuthorship W1945499848A5035038487 @default.
- W1945499848 hasAuthorship W1945499848A5063582061 @default.
- W1945499848 hasAuthorship W1945499848A5072020215 @default.
- W1945499848 hasConcept C12554922 @default.
- W1945499848 hasConcept C126322002 @default.
- W1945499848 hasConcept C134018914 @default.
- W1945499848 hasConcept C185592680 @default.
- W1945499848 hasConcept C2775984225 @default.
- W1945499848 hasConcept C2776286485 @default.
- W1945499848 hasConcept C2776991684 @default.
- W1945499848 hasConcept C2777274916 @default.
- W1945499848 hasConcept C2779768347 @default.
- W1945499848 hasConcept C55493867 @default.
- W1945499848 hasConcept C555293320 @default.
- W1945499848 hasConcept C71240020 @default.
- W1945499848 hasConcept C71924100 @default.
- W1945499848 hasConcept C83743174 @default.
- W1945499848 hasConcept C86803240 @default.
- W1945499848 hasConcept C98274493 @default.
- W1945499848 hasConceptScore W1945499848C12554922 @default.
- W1945499848 hasConceptScore W1945499848C126322002 @default.
- W1945499848 hasConceptScore W1945499848C134018914 @default.
- W1945499848 hasConceptScore W1945499848C185592680 @default.
- W1945499848 hasConceptScore W1945499848C2775984225 @default.
- W1945499848 hasConceptScore W1945499848C2776286485 @default.
- W1945499848 hasConceptScore W1945499848C2776991684 @default.
- W1945499848 hasConceptScore W1945499848C2777274916 @default.
- W1945499848 hasConceptScore W1945499848C2779768347 @default.
- W1945499848 hasConceptScore W1945499848C55493867 @default.
- W1945499848 hasConceptScore W1945499848C555293320 @default.
- W1945499848 hasConceptScore W1945499848C71240020 @default.
- W1945499848 hasConceptScore W1945499848C71924100 @default.
- W1945499848 hasConceptScore W1945499848C83743174 @default.
- W1945499848 hasConceptScore W1945499848C86803240 @default.
- W1945499848 hasConceptScore W1945499848C98274493 @default.
- W1945499848 hasIssue "2" @default.
- W1945499848 hasLocation W19454998481 @default.
- W1945499848 hasOpenAccess W1945499848 @default.
- W1945499848 hasPrimaryLocation W19454998481 @default.
- W1945499848 hasRelatedWork W1945499848 @default.
- W1945499848 hasRelatedWork W2031140101 @default.
- W1945499848 hasRelatedWork W2095577287 @default.
- W1945499848 hasRelatedWork W2170920019 @default.
- W1945499848 hasRelatedWork W2171450707 @default.
- W1945499848 hasRelatedWork W2319830026 @default.
- W1945499848 hasRelatedWork W2412182224 @default.
- W1945499848 hasRelatedWork W2419610760 @default.
- W1945499848 hasRelatedWork W3036226145 @default.
- W1945499848 hasRelatedWork W2773933061 @default.
- W1945499848 hasVolume "275" @default.
- W1945499848 isParatext "false" @default.
- W1945499848 isRetracted "false" @default.
- W1945499848 magId "1945499848" @default.
- W1945499848 workType "article" @default.