Matches in SemOpenAlex for { <https://semopenalex.org/work/W1945538340> ?p ?o ?g. }
- W1945538340 endingPage "38616" @default.
- W1945538340 startingPage "38591" @default.
- W1945538340 abstract "MYC, a potent oncogene located at chromosome locus 8q24.21, was identified initially by its involvement in Burkitt lymphoma with t(8;14)(q24;q32). MYC encodes a helix-loop-helix transcription factor that accentuates many cellular functions including proliferation, growth and apoptosis. MYC alterations also have been identified in other mature B-cell neoplasms and are associated with aggressive clinical behavior. There are several regulatory factors and dysregulated signaling that lead to MYC up-regulation in B-cell lymphomas. One typical example is the failure of physiological repressors such as Bcl6 or BLIMP1 to suppress MYC over-expression. In addition, MYC alterations are often developed concurrently with other genetic alterations that counteract the proapoptotic function of MYC. In this review, we discuss the physiologic function of MYC and the role that MYC likely plays in the pathogenesis of B-cell lymphomas. We also summarize the role MYC plays in the diagnosis, prognostication and various strategies to detect MYC rearrangement and expression." @default.
- W1945538340 created "2016-06-24" @default.
- W1945538340 creator A5000027373 @default.
- W1945538340 creator A5013543100 @default.
- W1945538340 creator A5054196722 @default.
- W1945538340 creator A5071672335 @default.
- W1945538340 date "2015-09-22" @default.
- W1945538340 modified "2023-09-26" @default.
- W1945538340 title "<i>MYC</i>-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management" @default.
- W1945538340 cites W1001409994 @default.
- W1945538340 cites W1165057505 @default.
- W1945538340 cites W12965686 @default.
- W1945538340 cites W1435607810 @default.
- W1945538340 cites W1506031925 @default.
- W1945538340 cites W1594164755 @default.
- W1945538340 cites W1603624799 @default.
- W1945538340 cites W1847174723 @default.
- W1945538340 cites W1862607355 @default.
- W1945538340 cites W1965254413 @default.
- W1945538340 cites W1965854549 @default.
- W1945538340 cites W1968075576 @default.
- W1945538340 cites W1970701525 @default.
- W1945538340 cites W1971659434 @default.
- W1945538340 cites W1971981721 @default.
- W1945538340 cites W1972105236 @default.
- W1945538340 cites W1972215727 @default.
- W1945538340 cites W1972780353 @default.
- W1945538340 cites W1973001092 @default.
- W1945538340 cites W1973878786 @default.
- W1945538340 cites W1977377125 @default.
- W1945538340 cites W1978672439 @default.
- W1945538340 cites W1978932947 @default.
- W1945538340 cites W1979922586 @default.
- W1945538340 cites W1982834279 @default.
- W1945538340 cites W1983370435 @default.
- W1945538340 cites W1988535436 @default.
- W1945538340 cites W1988817337 @default.
- W1945538340 cites W1988821953 @default.
- W1945538340 cites W1994791278 @default.
- W1945538340 cites W1995314727 @default.
- W1945538340 cites W1995926405 @default.
- W1945538340 cites W1997181504 @default.
- W1945538340 cites W1999080103 @default.
- W1945538340 cites W2000589976 @default.
- W1945538340 cites W2003820822 @default.
- W1945538340 cites W2006070956 @default.
- W1945538340 cites W2007477730 @default.
- W1945538340 cites W2007886976 @default.
- W1945538340 cites W2009949436 @default.
- W1945538340 cites W2011162627 @default.
- W1945538340 cites W2011843296 @default.
- W1945538340 cites W2013581703 @default.
- W1945538340 cites W2013729196 @default.
- W1945538340 cites W2015860777 @default.
- W1945538340 cites W2019135859 @default.
- W1945538340 cites W2019812127 @default.
- W1945538340 cites W2021536610 @default.
- W1945538340 cites W2024972915 @default.
- W1945538340 cites W2028584623 @default.
- W1945538340 cites W2028850684 @default.
- W1945538340 cites W2029473952 @default.
- W1945538340 cites W2029829614 @default.
- W1945538340 cites W2032681988 @default.
- W1945538340 cites W2035611379 @default.
- W1945538340 cites W2036698519 @default.
- W1945538340 cites W2037275886 @default.
- W1945538340 cites W2038009564 @default.
- W1945538340 cites W2038291983 @default.
- W1945538340 cites W2039010218 @default.
- W1945538340 cites W2041535798 @default.
- W1945538340 cites W2041541315 @default.
- W1945538340 cites W2042399069 @default.
- W1945538340 cites W2043622833 @default.
- W1945538340 cites W2045149893 @default.
- W1945538340 cites W2045546922 @default.
- W1945538340 cites W2045794991 @default.
- W1945538340 cites W2046371485 @default.
- W1945538340 cites W2048733157 @default.
- W1945538340 cites W2049317350 @default.
- W1945538340 cites W2052061810 @default.
- W1945538340 cites W2052284649 @default.
- W1945538340 cites W2056172893 @default.
- W1945538340 cites W2056319931 @default.
- W1945538340 cites W2056555760 @default.
- W1945538340 cites W2056641238 @default.
- W1945538340 cites W2057239580 @default.
- W1945538340 cites W2057319734 @default.
- W1945538340 cites W2058615001 @default.
- W1945538340 cites W2060484997 @default.
- W1945538340 cites W2062175368 @default.
- W1945538340 cites W2064223130 @default.
- W1945538340 cites W2065397600 @default.
- W1945538340 cites W2068606395 @default.
- W1945538340 cites W2069590838 @default.
- W1945538340 cites W2070012169 @default.
- W1945538340 cites W2071256596 @default.
- W1945538340 cites W2071306241 @default.
- W1945538340 cites W2074724450 @default.