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• W1945694870 abstract "The current pharmacotherapy for erectile dysfunction (ED) relies significantly on the use of phosphodiesterase type 5 (PDE5) inhibitors, but quite a proportion of ED patients are resistant to this therapy, necessitating a search for an alternative treatment. We reviewed available published data to analyze current evidence of hydrogen sulfide (H(2) S) as a novel pharmacotherapeutic agent with supportive role in sexual function.To discuss the role of H(2) S in erectile function, its possible mechanism of action, and how this knowledge may be exploited for therapeutic use.Pubmed and Medline search was conducted to identify original articles and reviews.Data from peer-reviewed publications.Animal studies using different species, including in vitro study done in humans, show evidence of H(2) S's pro-erectile effects. The mechanism behind is still unclear, but evidence in literature points out the involvement of K(+) (ATP) channel, modulation of protein with anti-erectile effects, as well as involvement of the nitrergic pathway through a complex cross-talk. A new drug called H(2) S-donating sildenafil (ACS6), which incorporated an H(2) S-donating moiety in sildenafil, has been developed. While more studies are still needed, this heralded a new pharmacotherapeutical approach, which is multipronged in nature.Given the mounting evidence of H(2) S's role in erectile function and how it appears to achieve its pro-erectile effects through different mechanisms, H(2) S represents a potentially important treatment alternative or adjunct to PDE5 inhibitors." @default.
• W1945694870 created "2016-06-24" @default.
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• W1945694870 date "2011-07-01" @default.
• W1945694870 modified "2023-09-27" @default.
• W1945694870 title "Effects of Hydrogen Sulfide on Erectile Function and Its Possible Mechanism(s) of Action" @default.
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• W1945694870 doi "https://doi.org/10.1111/j.1743-6109.2011.02279.x" @default.
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