Matches in SemOpenAlex for { <https://semopenalex.org/work/W1945730797> ?p ?o ?g. }
- W1945730797 endingPage "502" @default.
- W1945730797 startingPage "494" @default.
- W1945730797 abstract "Glioblastoma is one of the most frequent primary brain tumors and is characterized by aggressive clinical behavior and biologic heterogeneity. To evaluate the prognostic implication of cancer stem cell markers in glioblastoma, the expression of these markers was investigated in a large series of glioblastoma patients in relation to the survival rate. This series includes 88 cases of glioblastoma that were diagnosed at the Chonnam University Hwasun Hospital from 2004 to 2009. The expression of newly established stem cell markers (nestin, CD133 and CD15) was detected using immunohistochemical analysis. The presence of immunopositive tumor cells was evaluated and interpreted in comparison with the patients' survival data. The expression of nestin was high in 60 cases (68.2%). CD133 and CD15 were positive in 52 cases (59.1%) and 40 cases (45.5%), respectively. No statistically significant difference in patient survival according to stem cell marker expression was observed (P > 0.05). However, gross total resection or combined radiation therapy and chemotherapy significantly prolonged survival (P = 0.04 and P = 0.04). Cox's proportional hazards model showed that the gross total resection and combined radiation therapy and chemotherapy were independent prognostic factors. Although the correlation of stem cell marker expression with clinical outcome in glioma is of considerable interest, the data do not support their prognostic value in glioblastoma. Identification of the key cells in the glioblastoma population in the context of clinical outcomes will provide insight into the mechanism of brain tumorigenesis and will be of paramount importance in determining therapeutically appropriate targets." @default.
- W1945730797 created "2016-06-24" @default.
- W1945730797 creator A5020166156 @default.
- W1945730797 creator A5021191500 @default.
- W1945730797 creator A5030214712 @default.
- W1945730797 creator A5045517532 @default.
- W1945730797 creator A5063765949 @default.
- W1945730797 creator A5078389794 @default.
- W1945730797 creator A5090291890 @default.
- W1945730797 date "2011-01-27" @default.
- W1945730797 modified "2023-09-26" @default.
- W1945730797 title "The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas" @default.
- W1945730797 cites W116758555 @default.
- W1945730797 cites W133253872 @default.
- W1945730797 cites W1970530124 @default.
- W1945730797 cites W1975992482 @default.
- W1945730797 cites W1987937542 @default.
- W1945730797 cites W1988986134 @default.
- W1945730797 cites W1989715997 @default.
- W1945730797 cites W1989958716 @default.
- W1945730797 cites W2001544973 @default.
- W1945730797 cites W2001550066 @default.
- W1945730797 cites W2005545445 @default.
- W1945730797 cites W2009707285 @default.
- W1945730797 cites W2012962381 @default.
- W1945730797 cites W2018607339 @default.
- W1945730797 cites W2040942845 @default.
- W1945730797 cites W2041532272 @default.
- W1945730797 cites W2048160969 @default.
- W1945730797 cites W2054139397 @default.
- W1945730797 cites W2060551076 @default.
- W1945730797 cites W2065737043 @default.
- W1945730797 cites W2079356804 @default.
- W1945730797 cites W2087128761 @default.
- W1945730797 cites W2089233117 @default.
- W1945730797 cites W2095789123 @default.
- W1945730797 cites W2096287682 @default.
- W1945730797 cites W2108973415 @default.
- W1945730797 cites W2121749405 @default.
- W1945730797 cites W2123509170 @default.
- W1945730797 cites W2124078079 @default.
- W1945730797 cites W2140763084 @default.
- W1945730797 cites W2142047303 @default.
- W1945730797 cites W2152112132 @default.
- W1945730797 cites W2160934584 @default.
- W1945730797 cites W2167414381 @default.
- W1945730797 cites W2169752217 @default.
- W1945730797 cites W2762697978 @default.
- W1945730797 cites W4255289481 @default.
- W1945730797 cites W2004298851 @default.
- W1945730797 doi "https://doi.org/10.1111/j.1440-1789.2010.01194.x" @default.
- W1945730797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21269333" @default.
- W1945730797 hasPublicationYear "2011" @default.
- W1945730797 type Work @default.
- W1945730797 sameAs 1945730797 @default.
- W1945730797 citedByCount "75" @default.
- W1945730797 countsByYear W19457307972012 @default.
- W1945730797 countsByYear W19457307972013 @default.
- W1945730797 countsByYear W19457307972014 @default.
- W1945730797 countsByYear W19457307972015 @default.
- W1945730797 countsByYear W19457307972016 @default.
- W1945730797 countsByYear W19457307972017 @default.
- W1945730797 countsByYear W19457307972018 @default.
- W1945730797 countsByYear W19457307972019 @default.
- W1945730797 countsByYear W19457307972020 @default.
- W1945730797 countsByYear W19457307972021 @default.
- W1945730797 countsByYear W19457307972022 @default.
- W1945730797 countsByYear W19457307972023 @default.
- W1945730797 crossrefType "journal-article" @default.
- W1945730797 hasAuthorship W1945730797A5020166156 @default.
- W1945730797 hasAuthorship W1945730797A5021191500 @default.
- W1945730797 hasAuthorship W1945730797A5030214712 @default.
- W1945730797 hasAuthorship W1945730797A5045517532 @default.
- W1945730797 hasAuthorship W1945730797A5063765949 @default.
- W1945730797 hasAuthorship W1945730797A5078389794 @default.
- W1945730797 hasAuthorship W1945730797A5090291890 @default.
- W1945730797 hasConcept C10205521 @default.
- W1945730797 hasConcept C121608353 @default.
- W1945730797 hasConcept C126322002 @default.
- W1945730797 hasConcept C136302470 @default.
- W1945730797 hasConcept C136834591 @default.
- W1945730797 hasConcept C142724271 @default.
- W1945730797 hasConcept C143998085 @default.
- W1945730797 hasConcept C204232928 @default.
- W1945730797 hasConcept C2776194525 @default.
- W1945730797 hasConcept C2776694085 @default.
- W1945730797 hasConcept C2776804306 @default.
- W1945730797 hasConcept C2777738006 @default.
- W1945730797 hasConcept C2778227246 @default.
- W1945730797 hasConcept C2779130545 @default.
- W1945730797 hasConcept C28328180 @default.
- W1945730797 hasConcept C2908647359 @default.
- W1945730797 hasConcept C502942594 @default.
- W1945730797 hasConcept C509974204 @default.
- W1945730797 hasConcept C54355233 @default.
- W1945730797 hasConcept C55427017 @default.
- W1945730797 hasConcept C555283112 @default.
- W1945730797 hasConcept C71924100 @default.