Matches in SemOpenAlex for { <https://semopenalex.org/work/W1946004087> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1946004087 endingPage "43" @default.
- W1946004087 startingPage "38" @default.
- W1946004087 abstract "In a series of in vitro studies, both the soluble (plasmatic) coagulation system and the cellular (platelet-mediated) aspect of coagulation were shown to be extremely sensitive to relatively minor increases in hydrogen ion concentration. All studies became abnormal at pH 6.8. At pH 6.4, assays of the intrinsic and extrinsic coaglution systems, the polymerization of fibrinogen, and assay of the availability of platelet phospholipid (platelet factor 3) were twice prolonged over control values. Platelet aggregation was reduced by more than 50%. At pH 5.4 in vitro, platelet aggregation and plasma coagulation were both virtually abolished. Furthermore, previously formed platelet aggregates disaggregated at a slightly acid pH. Pepsin further enhanced platelet disaggregation. Because gastric acidity is normally two to four orders of magnitude greater than that which abolishes platelet aggregation and plasma clotting in vitro, and pepsin is present in abundance, we call attention to the probable antihemostatic effect of hydrocloric acid and pepsin in the upper gastrointestinal tract. This in vitro study may provide a rationale for meticulous regulation of intragastric pH in an effort to control upper gastrointestinal hemorrhage." @default.
- W1946004087 created "2016-06-24" @default.
- W1946004087 creator A5005530729 @default.
- W1946004087 creator A5067120976 @default.
- W1946004087 creator A5086561591 @default.
- W1946004087 creator A5090178362 @default.
- W1946004087 date "1978-01-01" @default.
- W1946004087 modified "2023-10-17" @default.
- W1946004087 title "Effect of acid and pepsin on blood coagulation and platelet aggregation" @default.
- W1946004087 cites W1590010444 @default.
- W1946004087 cites W1968307922 @default.
- W1946004087 cites W1992074229 @default.
- W1946004087 cites W2012214760 @default.
- W1946004087 cites W2012337800 @default.
- W1946004087 cites W2016033260 @default.
- W1946004087 cites W2023887745 @default.
- W1946004087 cites W2036786377 @default.
- W1946004087 cites W2050731479 @default.
- W1946004087 cites W2061875283 @default.
- W1946004087 cites W2092238809 @default.
- W1946004087 cites W2117566166 @default.
- W1946004087 cites W2167769713 @default.
- W1946004087 cites W2186444209 @default.
- W1946004087 cites W2333330110 @default.
- W1946004087 cites W2400544299 @default.
- W1946004087 cites W2400876429 @default.
- W1946004087 cites W2409604495 @default.
- W1946004087 cites W2440570505 @default.
- W1946004087 cites W2589416296 @default.
- W1946004087 cites W2923680121 @default.
- W1946004087 doi "https://doi.org/10.1016/0016-5085(78)90352-9" @default.
- W1946004087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21830" @default.
- W1946004087 hasPublicationYear "1978" @default.
- W1946004087 type Work @default.
- W1946004087 sameAs 1946004087 @default.
- W1946004087 citedByCount "462" @default.
- W1946004087 countsByYear W19460040872012 @default.
- W1946004087 countsByYear W19460040872013 @default.
- W1946004087 countsByYear W19460040872014 @default.
- W1946004087 countsByYear W19460040872015 @default.
- W1946004087 countsByYear W19460040872016 @default.
- W1946004087 countsByYear W19460040872017 @default.
- W1946004087 countsByYear W19460040872018 @default.
- W1946004087 countsByYear W19460040872019 @default.
- W1946004087 countsByYear W19460040872020 @default.
- W1946004087 countsByYear W19460040872021 @default.
- W1946004087 countsByYear W19460040872022 @default.
- W1946004087 countsByYear W19460040872023 @default.
- W1946004087 crossrefType "journal-article" @default.
- W1946004087 hasAuthorship W1946004087A5005530729 @default.
- W1946004087 hasAuthorship W1946004087A5067120976 @default.
- W1946004087 hasAuthorship W1946004087A5086561591 @default.
- W1946004087 hasAuthorship W1946004087A5090178362 @default.
- W1946004087 hasBestOaLocation W19460040871 @default.
- W1946004087 hasConcept C126322002 @default.
- W1946004087 hasConcept C16311235 @default.
- W1946004087 hasConcept C181199279 @default.
- W1946004087 hasConcept C185592680 @default.
- W1946004087 hasConcept C2778382381 @default.
- W1946004087 hasConcept C2993802102 @default.
- W1946004087 hasConcept C55493867 @default.
- W1946004087 hasConcept C71924100 @default.
- W1946004087 hasConcept C89560881 @default.
- W1946004087 hasConceptScore W1946004087C126322002 @default.
- W1946004087 hasConceptScore W1946004087C16311235 @default.
- W1946004087 hasConceptScore W1946004087C181199279 @default.
- W1946004087 hasConceptScore W1946004087C185592680 @default.
- W1946004087 hasConceptScore W1946004087C2778382381 @default.
- W1946004087 hasConceptScore W1946004087C2993802102 @default.
- W1946004087 hasConceptScore W1946004087C55493867 @default.
- W1946004087 hasConceptScore W1946004087C71924100 @default.
- W1946004087 hasConceptScore W1946004087C89560881 @default.
- W1946004087 hasIssue "1" @default.
- W1946004087 hasLocation W19460040871 @default.
- W1946004087 hasOpenAccess W1946004087 @default.
- W1946004087 hasPrimaryLocation W19460040871 @default.
- W1946004087 hasRelatedWork W198034794 @default.
- W1946004087 hasRelatedWork W1990632940 @default.
- W1946004087 hasRelatedWork W2000051223 @default.
- W1946004087 hasRelatedWork W2026325401 @default.
- W1946004087 hasRelatedWork W2091182287 @default.
- W1946004087 hasRelatedWork W2125080490 @default.
- W1946004087 hasRelatedWork W2292401026 @default.
- W1946004087 hasRelatedWork W2315537871 @default.
- W1946004087 hasRelatedWork W2396161778 @default.
- W1946004087 hasRelatedWork W2414263361 @default.
- W1946004087 hasVolume "74" @default.
- W1946004087 isParatext "false" @default.
- W1946004087 isRetracted "false" @default.
- W1946004087 magId "1946004087" @default.
- W1946004087 workType "article" @default.