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- W1946004772 abstract "We investigated long-term potentiation (LTP) at mossy fiber synapses on CA3 pyramidal neurons in the hippocampus. Using Ca2+ imaging techniques, we show here that when postsynaptic Ca2+ was sufficiently buffered so that [Ca2+]i did not rise during synaptic stimulation, the induction of mossy fiber LTP was prevented. In addition, induction of mossy fiber LTP was suppressed by postsynaptic injection of a peptide inhibitor of cAMP-dependent protein kinase. Finally, when ionotropic glutamate receptors were blocked, LTP depended on the postsynaptic release of Ca2+ from internal stores triggered by activation of metabotropic glutamate receptors. These results support the conclusion that mossy fiber LTP and LTP at other hippocampal synapses share a common induction mechanism involving an initial rise in postsynaptic [Ca2+]." @default.
- W1946004772 created "2016-06-24" @default.
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- W1946004772 date "1999-07-01" @default.
- W1946004772 modified "2023-09-23" @default.
- W1946004772 title "Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism" @default.
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- W1946004772 doi "https://doi.org/10.1038/10180" @default.
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