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• W19461878 endingPage "30" @default.
• W19461878 startingPage "117" @default.
• W19461878 abstract "De Ritis described the ratio between the serum levels of aspartate transaminase (AST) and alanine transaminase (ALT) almost 50 years ago. While initially described as a characteristic of acute viral hepatitis where ALT was usually higher than AST, other authors have subsequently found it useful in alcoholic hepatitis, where AST is usually higher than ALT. These interpretations are far too simplistic however as acute viral hepatitis can have AST greater than ALT, and this can be a sign of fulminant disease, while alcoholic hepatitis can have ALT greater than AST when several days have elapsed since alcohol exposure. The ratio therefore represents the time course and aggressiveness of disease that would be predicted from the relatively short half-life of AST (18 h) compared to ALT (36 h). In chronic viral illnesses such as chronic viral hepatitis and chronic alcoholism as well as non-alcoholic fatty liver disease, an elevated AST/ALT ratio is predictive of long terms complications including fibrosis and cirrhosis. There are methodological issues, particularly whether or not pyridoxal phosphate is used in the transaminase assays, and although this can have specific effects when patient samples are deficient in this vitamin, these method differences generally have mild effects on the usefulness of the assays or the ratio. Ideally laboratories should be using pyridoxal phosphate supplemented assays in alcoholic, elderly and cancer patients who may be pyridoxine deplete. Ideally all laboratories reporting abnormal ALT should also report AST and calculate the De Ritis ratio because it provides useful diagnostic and prognostic information." @default.
• W19461878 created "2016-06-24" @default.
• W19461878 creator A5001963098 @default.
• W19461878 creator A5047104654 @default.
• W19461878 date "2013-11-01" @default.
• W19461878 modified "2023-10-17" @default.
• W19461878 title "The de ritis ratio: the test of time." @default.
• W19461878 cites W103339158 @default.
• W19461878 cites W106560845 @default.
• W19461878 cites W112345076 @default.
• W19461878 cites W115629402 @default.
• W19461878 cites W118162453 @default.
• W19461878 cites W1485973300 @default.
• W19461878 cites W1510849563 @default.
• W19461878 cites W151589882 @default.
• W19461878 cites W1559068584 @default.
• W19461878 cites W1571738433 @default.
• W19461878 cites W1574875639 @default.
• W19461878 cites W1575003276 @default.
• W19461878 cites W1605796582 @default.
• W19461878 cites W16260949 @default.
• W19461878 cites W1776414110 @default.
• W19461878 cites W1858542342 @default.
• W19461878 cites W1894134455 @default.
• W19461878 cites W1906361798 @default.
• W19461878 cites W1928447183 @default.
• W19461878 cites W1932274971 @default.
• W19461878 cites W195314437 @default.
• W19461878 cites W1958889977 @default.
• W19461878 cites W1966367245 @default.
• W19461878 cites W1967711533 @default.
• W19461878 cites W1969295126 @default.
• W19461878 cites W1971232164 @default.
• W19461878 cites W1971991764 @default.
• W19461878 cites W1976267088 @default.
• W19461878 cites W1977834033 @default.
• W19461878 cites W1981460639 @default.
• W19461878 cites W1982998620 @default.
• W19461878 cites W1983417944 @default.
• W19461878 cites W1985155553 @default.
• W19461878 cites W1985330026 @default.
• W19461878 cites W1985834931 @default.
• W19461878 cites W1987349835 @default.
• W19461878 cites W1987638423 @default.
• W19461878 cites W1991894577 @default.
• W19461878 cites W1992046038 @default.
• W19461878 cites W1996035307 @default.
• W19461878 cites W1997865776 @default.
• W19461878 cites W1999931740 @default.
• W19461878 cites W2000966089 @default.
• W19461878 cites W2001491795 @default.
• W19461878 cites W2001837599 @default.
• W19461878 cites W2002081949 @default.
• W19461878 cites W2003758171 @default.
• W19461878 cites W2004384181 @default.
• W19461878 cites W2008661549 @default.
• W19461878 cites W2009444793 @default.
• W19461878 cites W2020508492 @default.
• W19461878 cites W2027275383 @default.
• W19461878 cites W2028883883 @default.
• W19461878 cites W2034188379 @default.
• W19461878 cites W2036118404 @default.
• W19461878 cites W2040528293 @default.
• W19461878 cites W2040668343 @default.
• W19461878 cites W2042062317 @default.
• W19461878 cites W2042324298 @default.
• W19461878 cites W2047606688 @default.
• W19461878 cites W2051307146 @default.
• W19461878 cites W2054306176 @default.
• W19461878 cites W2056386880 @default.
• W19461878 cites W2056855826 @default.
• W19461878 cites W2057077123 @default.
• W19461878 cites W2058383228 @default.
• W19461878 cites W2058764440 @default.
• W19461878 cites W2059329220 @default.
• W19461878 cites W205992603 @default.
• W19461878 cites W2060847352 @default.
• W19461878 cites W2062571307 @default.
• W19461878 cites W2064132909 @default.
• W19461878 cites W206690762 @default.
• W19461878 cites W2067552641 @default.
• W19461878 cites W2072390396 @default.
• W19461878 cites W2073002951 @default.
• W19461878 cites W2074705421 @default.
• W19461878 cites W2077058718 @default.
• W19461878 cites W2083320833 @default.
• W19461878 cites W2085097924 @default.
• W19461878 cites W2087829753 @default.
• W19461878 cites W2089535377 @default.
• W19461878 cites W2090879914 @default.
• W19461878 cites W2091065440 @default.
• W19461878 cites W2091199205 @default.
• W19461878 cites W2092238408 @default.
• W19461878 cites W2093398377 @default.
• W19461878 cites W2096498890 @default.
• W19461878 cites W2104826300 @default.
• W19461878 cites W2108085270 @default.
• W19461878 cites W2113340037 @default.

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