Matches in SemOpenAlex for { <https://semopenalex.org/work/W1946191191> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1946191191 endingPage "9" @default.
- W1946191191 startingPage "1365" @default.
- W1946191191 abstract "We determined the reference interval for the carboxyterminal propeptide of type I procollagen (PICP), an indicator of the synthesis of type I collagen, in cerebrospinal fluid (CSF) by studying 32 infants and children, ages less than or equal to 15 years. The concentration of PICP is age dependent, with particularly high concentrations occurring in children younger than 1.5 years. In older children the concentration is stable (reference interval 20-92 micrograms/L). We also investigated the possibility that PICP in CSF could reflect local fibroproliferative changes in the arachnoid in a cohort of 42 children with acute lymphoblastic leukemia who were monitored by repeated sampling in connection with intrathecal therapy. Initially, there was no difference in PICP between the children with newly diagnosed leukemia and the controls. PICP concentrations were significantly higher (P less than 0.01) during intrathecal methotrexate therapy, with median values above the reference interval. Continuous corticosteroid treatment was associated with a significant decrease in PICP (P less than 0.02 and P less than 0.01, respectively, in two groups treated according to different protocols), close to the lower limit of the reference interval. Intrathecally administered methotrexate and systemic corticosteroid treatment are known to be associated with the development of arachnoiditis and with general repression of collagen synthesis, respectively. We conclude that PICP in CSF is a sensitive indicator of local fibroproliferation and ongoing collagen synthesis." @default.
- W1946191191 created "2016-06-24" @default.
- W1946191191 creator A5001613842 @default.
- W1946191191 creator A5005931323 @default.
- W1946191191 creator A5021813484 @default.
- W1946191191 creator A5070507098 @default.
- W1946191191 date "1991-08-01" @default.
- W1946191191 modified "2023-09-23" @default.
- W1946191191 title "Carboxyterminal propeptide of type I procollagen in cerebrospinal fluid in childhood and in children with leukemia undergoing intrathecal treatment." @default.
- W1946191191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1868595" @default.
- W1946191191 hasPublicationYear "1991" @default.
- W1946191191 type Work @default.
- W1946191191 sameAs 1946191191 @default.
- W1946191191 citedByCount "2" @default.
- W1946191191 crossrefType "journal-article" @default.
- W1946191191 hasAuthorship W1946191191A5001613842 @default.
- W1946191191 hasAuthorship W1946191191A5005931323 @default.
- W1946191191 hasAuthorship W1946191191A5021813484 @default.
- W1946191191 hasAuthorship W1946191191A5070507098 @default.
- W1946191191 hasConcept C126322002 @default.
- W1946191191 hasConcept C134018914 @default.
- W1946191191 hasConcept C141071460 @default.
- W1946191191 hasConcept C157820659 @default.
- W1946191191 hasConcept C2776804153 @default.
- W1946191191 hasConcept C2778461978 @default.
- W1946191191 hasConcept C2779401946 @default.
- W1946191191 hasConcept C2779651940 @default.
- W1946191191 hasConcept C2781059491 @default.
- W1946191191 hasConcept C2909962599 @default.
- W1946191191 hasConcept C44249647 @default.
- W1946191191 hasConcept C64348721 @default.
- W1946191191 hasConcept C71924100 @default.
- W1946191191 hasConcept C90924648 @default.
- W1946191191 hasConceptScore W1946191191C126322002 @default.
- W1946191191 hasConceptScore W1946191191C134018914 @default.
- W1946191191 hasConceptScore W1946191191C141071460 @default.
- W1946191191 hasConceptScore W1946191191C157820659 @default.
- W1946191191 hasConceptScore W1946191191C2776804153 @default.
- W1946191191 hasConceptScore W1946191191C2778461978 @default.
- W1946191191 hasConceptScore W1946191191C2779401946 @default.
- W1946191191 hasConceptScore W1946191191C2779651940 @default.
- W1946191191 hasConceptScore W1946191191C2781059491 @default.
- W1946191191 hasConceptScore W1946191191C2909962599 @default.
- W1946191191 hasConceptScore W1946191191C44249647 @default.
- W1946191191 hasConceptScore W1946191191C64348721 @default.
- W1946191191 hasConceptScore W1946191191C71924100 @default.
- W1946191191 hasConceptScore W1946191191C90924648 @default.
- W1946191191 hasIssue "8" @default.
- W1946191191 hasLocation W19461911911 @default.
- W1946191191 hasOpenAccess W1946191191 @default.
- W1946191191 hasPrimaryLocation W19461911911 @default.
- W1946191191 hasRelatedWork W155373676 @default.
- W1946191191 hasRelatedWork W1861834628 @default.
- W1946191191 hasRelatedWork W1946191191 @default.
- W1946191191 hasRelatedWork W2018039297 @default.
- W1946191191 hasRelatedWork W2023608209 @default.
- W1946191191 hasRelatedWork W2030395315 @default.
- W1946191191 hasRelatedWork W2374537282 @default.
- W1946191191 hasRelatedWork W2395235907 @default.
- W1946191191 hasRelatedWork W2526568076 @default.
- W1946191191 hasRelatedWork W4236694906 @default.
- W1946191191 hasVolume "37" @default.
- W1946191191 isParatext "false" @default.
- W1946191191 isRetracted "false" @default.
- W1946191191 magId "1946191191" @default.
- W1946191191 workType "article" @default.