FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1946207508> ?p ?o ?g. }

• W1946207508 endingPage "4887" @default.
• W1946207508 startingPage "4874" @default.
• W1946207508 abstract "ABSTRACT In response to nitrogen starvation, diploid cells of the yeast Saccharomyces cerevisiae differentiate to a filamentous growth form known as pseudohyphal differentiation. Filamentous growth is regulated by elements of the pheromone mitogen-activated protein (MAP) kinase cascade and a second signaling cascade involving the receptor Gpr1, the Gα protein Gpa2, Ras2, and cyclic AMP (cAMP). We show here that the Gpr1-Gpa2-cAMP pathway signals via the cAMP-dependent protein kinase, protein kinase A (PKA), to regulate pseudohyphal differentiation. Activation of PKA by mutation of the regulatory subunit Bcy1 enhances filamentous growth. Mutation and overexpression of the PKA catalytic subunits reveal that the Tpk2 catalytic subunit activates filamentous growth, whereas the Tpk1 and Tpk3 catalytic subunits inhibit filamentous growth. The PKA pathway regulates unipolar budding and agar invasion, whereas the MAP kinase cascade regulates cell elongation and invasion. Epistasis analysis supports a model in which PKA functions downstream of the Gpr1 receptor and the Gpa2 and Ras2 G proteins. Activation of filamentous growth by PKA does not require the transcription factors Ste12 and Tec1 of the MAP kinase cascade, Phd1, or the PKA targets Msn2 and Msn4. PKA signals pseudohyphal growth, in part, by regulating Flo8-dependent expression of the cell surface flocculin Flo11. In summary, the cAMP-dependent protein kinase plays an intimate positive and negative role in regulating filamentous growth, and these findings may provide insight into the roles of PKA in mating, morphogenesis, and virulence in other yeasts and pathogenic fungi." @default.
• W1946207508 created "2016-06-24" @default.
• W1946207508 creator A5052159588 @default.
• W1946207508 creator A5052168116 @default.
• W1946207508 date "1999-07-01" @default.
• W1946207508 modified "2023-10-11" @default.
• W1946207508 title "Cyclic AMP-Dependent Protein Kinase Regulates Pseudohyphal Differentiation in <i>Saccharomyces cerevisiae</i>" @default.
• W1946207508 cites W1498936428 @default.
• W1946207508 cites W1600400967 @default.
• W1946207508 cites W1762562606 @default.
• W1946207508 cites W1804286624 @default.
• W1946207508 cites W1902685772 @default.
• W1946207508 cites W1967390330 @default.
• W1946207508 cites W1974605099 @default.
• W1946207508 cites W1978242911 @default.
• W1946207508 cites W1978828097 @default.
• W1946207508 cites W1991445188 @default.
• W1946207508 cites W1998871484 @default.
• W1946207508 cites W1999340863 @default.
• W1946207508 cites W2004432410 @default.
• W1946207508 cites W2006733565 @default.
• W1946207508 cites W2008014792 @default.
• W1946207508 cites W2014449180 @default.
• W1946207508 cites W2014931848 @default.
• W1946207508 cites W2024833672 @default.
• W1946207508 cites W2032432799 @default.
• W1946207508 cites W2042952021 @default.
• W1946207508 cites W2043296955 @default.
• W1946207508 cites W2051038693 @default.
• W1946207508 cites W2057952028 @default.
• W1946207508 cites W2060742513 @default.
• W1946207508 cites W2060913542 @default.
• W1946207508 cites W2066955442 @default.
• W1946207508 cites W2073750911 @default.
• W1946207508 cites W2074204387 @default.
• W1946207508 cites W2075473569 @default.
• W1946207508 cites W2089108869 @default.
• W1946207508 cites W2093434319 @default.
• W1946207508 cites W2096868139 @default.
• W1946207508 cites W2097283846 @default.
• W1946207508 cites W2099564486 @default.
• W1946207508 cites W2100057937 @default.
• W1946207508 cites W2100779584 @default.
• W1946207508 cites W2100866112 @default.
• W1946207508 cites W2101882623 @default.
• W1946207508 cites W2113070980 @default.
• W1946207508 cites W2120326214 @default.
• W1946207508 cites W2127552778 @default.
• W1946207508 cites W2131977749 @default.
• W1946207508 cites W2132416603 @default.
• W1946207508 cites W2132444456 @default.
• W1946207508 cites W2137990078 @default.
• W1946207508 cites W2147478719 @default.
• W1946207508 cites W2149824831 @default.
• W1946207508 cites W2150904401 @default.
• W1946207508 cites W2154124725 @default.
• W1946207508 cites W2155462663 @default.
• W1946207508 cites W2165113697 @default.
• W1946207508 cites W2165130891 @default.
• W1946207508 cites W2165238717 @default.
• W1946207508 cites W2169832274 @default.
• W1946207508 cites W2483519293 @default.
• W1946207508 cites W4240065971 @default.
• W1946207508 doi "https://doi.org/10.1128/mcb.19.7.4874" @default.
• W1946207508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/84286" @default.
• W1946207508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10373537" @default.
• W1946207508 hasPublicationYear "1999" @default.
• W1946207508 type Work @default.
• W1946207508 sameAs 1946207508 @default.
• W1946207508 citedByCount "340" @default.
• W1946207508 countsByYear W19462075082012 @default.
• W1946207508 countsByYear W19462075082013 @default.
• W1946207508 countsByYear W19462075082014 @default.
• W1946207508 countsByYear W19462075082015 @default.
• W1946207508 countsByYear W19462075082016 @default.
• W1946207508 countsByYear W19462075082017 @default.
• W1946207508 countsByYear W19462075082018 @default.
• W1946207508 countsByYear W19462075082019 @default.
• W1946207508 countsByYear W19462075082020 @default.
• W1946207508 countsByYear W19462075082021 @default.
• W1946207508 countsByYear W19462075082022 @default.
• W1946207508 countsByYear W19462075082023 @default.
• W1946207508 crossrefType "journal-article" @default.
• W1946207508 hasAuthorship W1946207508A5052159588 @default.
• W1946207508 hasAuthorship W1946207508A5052168116 @default.
• W1946207508 hasBestOaLocation W19462075081 @default.
• W1946207508 hasConcept C184235292 @default.
• W1946207508 hasConcept C2777576037 @default.
• W1946207508 hasConcept C2779222958 @default.
• W1946207508 hasConcept C54355233 @default.
• W1946207508 hasConcept C55493867 @default.
• W1946207508 hasConcept C86803240 @default.
• W1946207508 hasConcept C95444343 @default.
• W1946207508 hasConcept C97029542 @default.
• W1946207508 hasConceptScore W1946207508C184235292 @default.
• W1946207508 hasConceptScore W1946207508C2777576037 @default.
• W1946207508 hasConceptScore W1946207508C2779222958 @default.
• W1946207508 hasConceptScore W1946207508C54355233 @default.

• next