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- W19462218 abstract "Critical limb ischemia (CLI) is defined as ischemia that threatens the survival of limbs, which occurs when the arterial blood flow is not sufficient to meet the metabolic demands of the resting tissue and muscle. It occurs in 1–2% of patients greater than 50 years old with peripheral arterial disease and in contrast to the relatively benign course of mild to moderate claudication associated with peripheral artery disease, CLI leads to amputation unless arterial perfusion is recovered. Rest pain, ischemic ulcers, and gangrene are additional major clinical manifestations of CLI. Insufficient neovascularization and the subsequent lack of adequate blood perfusion of the affected limbs may lead to limb loss or even fatal complications. Thus, neovascularization via the processes of angiogenesis and arteriogenesis is essential to alleviate the clinical syndrome and to rescue limb function. The concept of promoting angiogenesis for the treatment of CLI was proposed a few decades ago after many preclinical studies generally supported this novel therapeutic approach. However, clinical use of various proangiogenic therapies to treat patients with CLI has not achieved the expectations predicted by preclinical animal models. Thus, successful translation of preclinical findings to clinical therapy will require new knowledge of the fundamental mechanisms of neovascularization." @default.
- W19462218 created "2016-06-24" @default.
- W19462218 creator A5073365279 @default.
- W19462218 date "2012-01-01" @default.
- W19462218 modified "2023-10-03" @default.
- W19462218 title "Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges" @default.
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