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- W1946249145 abstract "During ribosomal translation, the two ribosomal subunits remain associated through intersubunit bridges, despite rapid large-scale intersubunit rotation. The absence of large barriers hindering rotation is a prerequisite for rapid rotation. Here, we investigate how such a flat free-energy landscape is achieved, in particular considering the large shifts the bridges undergo at the periphery. The dynamics and energetics of the intersubunit contact network are studied using molecular dynamics simulations of the prokaryotic ribosome in intermediate states of spontaneous translocation. Based on observed occupancies of intersubunit contacts, residues were grouped into clusters. In addition to the central contact clusters, peripheral clusters were found to maintain strong steady interactions by changing contacts in the course of rotation. The peripheral B1 bridges are stabilized by a changing contact pattern of charged residues that adapts to the rotational state. In contrast, steady strong interactions of the B4 bridge are ensured by the flexible helix H34 following the movement of protein S15. The tRNAs which span the subunits contribute to the intersubunit binding enthalpy to an almost constant degree, despite their different positions in the ribosome. These mechanisms keep the intersubunit interaction strong and steady during rotation, thereby preventing dissociation and enabling rapid rotation." @default.
- W1946249145 created "2016-06-24" @default.
- W1946249145 creator A5007875950 @default.
- W1946249145 creator A5031556547 @default.
- W1946249145 creator A5045212144 @default.
- W1946249145 creator A5058863190 @default.
- W1946249145 date "2015-06-24" @default.
- W1946249145 modified "2023-09-25" @default.
- W1946249145 title "Dynamic contact network between ribosomal subunits enables rapid large-scale rotation during spontaneous translocation" @default.
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- W1946249145 doi "https://doi.org/10.1093/nar/gkv649" @default.
- W1946249145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4538834" @default.
- W1946249145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26109353" @default.
- W1946249145 hasPublicationYear "2015" @default.
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