FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1946281621> ?p ?o ?g. }

• W1946281621 endingPage "544" @default.
• W1946281621 startingPage "534" @default.
• W1946281621 abstract "Different VGF peptides derived from Vgf, originally identified as a nerve growth factor responsive gene, have been detected in neurons within the central and peripheral nervous system and in various endocrine cells. In the current study, we have evaluated the ability of TLQP-21, a VGF-derived peptide, to protect, in a dose- and time-dependent manner, primary cultures of rat cerebellar granule cells (CGCs) from serum and potassium deprivation-induced cell death. We demonstrated that TLQP-21 increased survival of CGCs by decreasing the degree of apoptosis as assessed by cell viability and DNA fragmentation. Moreover, TLQP-21 significantly activated extracellular signal-regulated kinase 1/2, serine/threonine protein kinase, and c-jun N-terminal kinase phosphorylation, while decreased the extent of protein kinase C phosphorylation, as demonstrated by western blot analysis. In addition, TLQP-21 induced significant increase in intracellular calcium (as measured by fura-2AM) in about 60% of the recorded neurons. Taken together, the present results demonstrate that TLQP-21 promotes the survival of CGCs via pathways involving, within few minutes, modulation of kinases associated with CGCs survival, and by increasing intracellular calcium which can contribute to the neuroprotective effect of the peptide." @default.
• W1946281621 created "2016-06-24" @default.
• W1946281621 creator A5010514068 @default.
• W1946281621 creator A5014009825 @default.
• W1946281621 creator A5032288817 @default.
• W1946281621 creator A5054899915 @default.
• W1946281621 creator A5055411337 @default.
• W1946281621 creator A5077767751 @default.
• W1946281621 creator A5080766515 @default.
• W1946281621 creator A5089278763 @default.
• W1946281621 date "2007-10-17" @default.
• W1946281621 modified "2023-10-17" @default.
• W1946281621 title "TLQP‐21, a neuroendocrine VGF‐derived peptide, prevents cerebellar granule cells death induced by serum and potassium deprivation" @default.
• W1946281621 cites W1523782066 @default.
• W1946281621 cites W1540436551 @default.
• W1946281621 cites W1562796888 @default.
• W1946281621 cites W1734831379 @default.
• W1946281621 cites W1779147517 @default.
• W1946281621 cites W1886438078 @default.
• W1946281621 cites W1970275243 @default.
• W1946281621 cites W1970328692 @default.
• W1946281621 cites W1976441097 @default.
• W1946281621 cites W1981322456 @default.
• W1946281621 cites W1986559713 @default.
• W1946281621 cites W1989642979 @default.
• W1946281621 cites W1991972636 @default.
• W1946281621 cites W2000147383 @default.
• W1946281621 cites W2007837805 @default.
• W1946281621 cites W2010705776 @default.
• W1946281621 cites W2014557719 @default.
• W1946281621 cites W2017291646 @default.
• W1946281621 cites W2022746546 @default.
• W1946281621 cites W2038671917 @default.
• W1946281621 cites W2040163240 @default.
• W1946281621 cites W2044589178 @default.
• W1946281621 cites W2048121649 @default.
• W1946281621 cites W2052226492 @default.
• W1946281621 cites W2072286244 @default.
• W1946281621 cites W2073046696 @default.
• W1946281621 cites W2073302735 @default.
• W1946281621 cites W2074021811 @default.
• W1946281621 cites W2079539712 @default.
• W1946281621 cites W2086262311 @default.
• W1946281621 cites W2090840497 @default.
• W1946281621 cites W2091598446 @default.
• W1946281621 cites W2097767970 @default.
• W1946281621 cites W2097914522 @default.
• W1946281621 cites W2102410706 @default.
• W1946281621 cites W2102527735 @default.
• W1946281621 cites W2107100596 @default.
• W1946281621 cites W2118897660 @default.
• W1946281621 cites W2119818922 @default.
• W1946281621 cites W2125779862 @default.
• W1946281621 cites W2128994713 @default.
• W1946281621 cites W2139223838 @default.
• W1946281621 cites W2139488506 @default.
• W1946281621 cites W2149592882 @default.
• W1946281621 cites W2155696186 @default.
• W1946281621 cites W2157423347 @default.
• W1946281621 cites W2169251397 @default.
• W1946281621 cites W4254872482 @default.
• W1946281621 cites W4327766731 @default.
• W1946281621 doi "https://doi.org/10.1111/j.1471-4159.2007.05068.x" @default.
• W1946281621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18173805" @default.
• W1946281621 hasPublicationYear "2007" @default.
• W1946281621 type Work @default.
• W1946281621 sameAs 1946281621 @default.
• W1946281621 citedByCount "30" @default.
• W1946281621 countsByYear W19462816212012 @default.
• W1946281621 countsByYear W19462816212013 @default.
• W1946281621 countsByYear W19462816212015 @default.
• W1946281621 countsByYear W19462816212017 @default.
• W1946281621 countsByYear W19462816212018 @default.
• W1946281621 countsByYear W19462816212019 @default.
• W1946281621 countsByYear W19462816212020 @default.
• W1946281621 countsByYear W19462816212021 @default.
• W1946281621 countsByYear W19462816212022 @default.
• W1946281621 countsByYear W19462816212023 @default.
• W1946281621 crossrefType "journal-article" @default.
• W1946281621 hasAuthorship W1946281621A5010514068 @default.
• W1946281621 hasAuthorship W1946281621A5014009825 @default.
• W1946281621 hasAuthorship W1946281621A5032288817 @default.
• W1946281621 hasAuthorship W1946281621A5054899915 @default.
• W1946281621 hasAuthorship W1946281621A5055411337 @default.
• W1946281621 hasAuthorship W1946281621A5077767751 @default.
• W1946281621 hasAuthorship W1946281621A5080766515 @default.
• W1946281621 hasAuthorship W1946281621A5089278763 @default.
• W1946281621 hasBestOaLocation W19462816211 @default.
• W1946281621 hasConcept C11960822 @default.
• W1946281621 hasConcept C126322002 @default.
• W1946281621 hasConcept C134018914 @default.
• W1946281621 hasConcept C169760540 @default.
• W1946281621 hasConcept C181080969 @default.
• W1946281621 hasConcept C184235292 @default.
• W1946281621 hasConcept C190283241 @default.
• W1946281621 hasConcept C195794163 @default.
• W1946281621 hasConcept C25498285 @default.
• W1946281621 hasConcept C31573885 @default.

• next