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• W1946284923 endingPage "1879" @default.
• W1946284923 startingPage "1868" @default.
• W1946284923 abstract "Alloimmunization against red blood cells (RBCs) is the main immunological risk associated with transfusion in patients with sickle cell disease (SCD). However, about 50-70% of SCD patients never get immunized despite frequent transfusion. In murine models, CD4(+) T cells play a key role in RBC alloimmunization. We therefore explored and compared the CD4(+) T-cell phenotypes and functions between a group of SCD patients (n = 11) who never became immunized despite a high transfusion regimen and a group of SCD patients (n = 10) who had become immunized (at least against Kidd antigen b) after a low transfusion regimen. We studied markers of CD4(+) T-cell function, including TLR, that directly control lymphocyte function, and their spontaneous cytokine production. We also tested responders for the cytokine profile in response to Kidd antigen b peptides. Low TLR2/TLR3 expression and, unexpectedly, strong expression of CD40 on CD4(+) T cells were associated with the nonresponder status, whereas spontaneous expression of IL-10 by CD4(+) T cells and weak Tbet expression were associated with the responder status. A Th17 profile was predominant in responders when stimulated by Jb(k) . These findings implicate CD4(+) T cells in alloimmunization in humans and suggest that they may be exploited to differentiate responders from nonresponders." @default.
• W1946284923 created "2016-06-24" @default.
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• W1946284923 date "2015-04-15" @default.
• W1946284923 modified "2023-10-18" @default.
• W1946284923 title "Phenotypic differences of CD4⁺T cells in response to red blood cell immunization in transfused sickle cell disease patients" @default.
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• W1946284923 doi "https://doi.org/10.1002/eji.201445187" @default.
• W1946284923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25763868" @default.
• W1946284923 hasPublicationYear "2015" @default.
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