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- W194633045 abstract "The generation of neurons from progenitor cells is regulated at several steps, including proliferation, lineage commitment, overt differentiation, and survival. The development of neurotrophin responsiveness in sympathetic neurons has been studied extensively in chick and in mouse. In the rat, antibody markers, which permit the isolation of SA progenitors at different stages of development, have been developed. Thus, the acquisition of neurotrophin responsiveness can be studied in relation to a lineage-commitment process. Moreover, it has been possible to generate immortalized clonal cell lines from SA progenitors, facilitating molecular biological studies. This chapter discusses what has been learned from such cell lines about the regulation of neurotrophin responsiveness during sympathetic neurogenesis and compares this to the information obtained from recent studies of normal sympathetic neuroblasts. The chapter also illustrates how a combination of experiments in both normal and immortalized sympathoadrenal progenitor cells has led to new insights concerning the regulation and function of nerve growth factor receptors during sympathetic neuron differentiation. The main conclusions are, first, that p75 enhances signal transduction through the TrkA receptor and that this enhanced signaling promotes relatively late events in the maturation of sympathetic neurons and, second, that sympathetic neuroblasts undergo a developmental switch in neurotrophin receptor expression and that this switch is in part controlled by the neurotrophins themselves via autoregulatory and cross-regulatory feedback loops." @default.
- W194633045 created "2016-06-24" @default.
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- W194633045 creator A5045886444 @default.
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- W194633045 date "1995-01-01" @default.
- W194633045 modified "2023-09-24" @default.
- W194633045 title "The Regulation and Function of NGF Receptors in Normal and Immortalized Sympathoadrenal Progenitor Cells" @default.
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- W194633045 doi "https://doi.org/10.1016/b978-0-08-042527-6.50017-1" @default.
- W194633045 hasPublicationYear "1995" @default.
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