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- W1946332788 abstract "Mammalian hck, a member of the src family of tyrosine kinases, is expressed predominantly in cells of the myeloid and B-lymphoid lineages. Using mutational analysis, we have investigated the molecular basis of two immunoreactive forms of murine hck of 56 and 59 kDa found in numerous hemopoietic cell types. Our results indicate that translation of murine p59hck initiates from a CTG codon located 21 codons 5' of an ATG that is utilized to generate p56hck. We provide evidence that two human hck isoforms are generated by the same mechanism. Subcellular fractionation studies reveal that while p59hck and p56hck are associated with membranes of various murine B-lymphoid and myeloid cell lines, p59hck alone is also located in the cytosol. In contrast to membrane-associated p59hck, which is metabolically labeled with [3H]myristic acid and exhibits amphiphilic properties in Triton X-114 detergent, cytosolic p59hck is hydrophilic, suggesting that it is not acylated. Possible mechanisms are proposed to account for these observations." @default.
- W1946332788 created "2016-06-24" @default.
- W1946332788 creator A5010975969 @default.
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- W1946332788 creator A5082131007 @default.
- W1946332788 creator A5082722222 @default.
- W1946332788 creator A5083285188 @default.
- W1946332788 date "1991-09-01" @default.
- W1946332788 modified "2023-09-26" @default.
- W1946332788 title "Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization." @default.
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- W1946332788 doi "https://doi.org/10.1128/mcb.11.9.4363" @default.
- W1946332788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/361298" @default.
- W1946332788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1875927" @default.
- W1946332788 hasPublicationYear "1991" @default.
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