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- W1946367095 abstract "This editorial refers to ‘SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload’ by G. Wu et al. , pp. 203–215. Cardiac hypertrophy is an adaptive process during which cardiomyocytes increase in size in response to various mechanical and hormonal stimuli. Cardiac hypertrophy develops under certain physiological conditions such as pregnancy and exercise, resulting in improved cardiac output to meet the increased oxygen demands. Of note, this physiological cardiac growth is reversible. In contrast, pathological cardiac hypertrophy is an irreversible tissue remodelling that develops in response to prolonged exposure to stress signals. Although both pathological and physiological hypertrophy initially demonstrate enhanced cardiac output, chronic exposure to pathological stimuli eventually leads to impaired cardiac functions. Indeed, pathological hypertrophy serves as an independent risk factor for serious cardiovascular diseases such as heart failure. With a view to developing therapeutics for this condition, molecular mechanisms underlying pathological hypertrophy have been extensively studied.1 Among many signalling pathways identified in cardiomyocytes, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is one of the significant signalling pathways involved in this process.2 IL-6 family cytokines play a critical …" @default.
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- W1946367095 date "2015-06-15" @default.
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- W1946367095 title "SH2B1: a new player in the regulation of cardiac hypertrophic response in failing hearts: Figure 1" @default.
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- W1946367095 doi "https://doi.org/10.1093/cvr/cvv172" @default.
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