Matches in SemOpenAlex for { <https://semopenalex.org/work/W194639418> ?p ?o ?g. }
- W194639418 endingPage "212" @default.
- W194639418 startingPage "197" @default.
- W194639418 abstract "The evidence that supports the hypothesis that insulin and LH both regulate ovarian androgen production was presented. The most dramatic clinical example of the association between hyperinsulinemia and hyperandrogenism is the HAIR-AN syndrome. Our hypothesis is that, in the HAIR-AN syndrome, the severe insulin resistance causes a compensatory hyperinsulinemia, which stimulates ovarian androgen production if adequate LH is present. The acanthosis nigricans is an epiphenomenon of the syndrome. Acanthosis nigricans is a dermatologic manifestation of severe insulin resistance. In vitro evidence suggests that insulin and IGF-I stimulate androgen production in incubations of human stroma and theca. The stromatropic effects of insulin may sensitize the stroma to the stimulatory effects of LH. In some hyperandrogenic-insulin-resistant women, a glucose load appears to produce an acute rise in circulating androgens. The magnitude of the rise in circulating androgens is proportional to the magnitude of the insulin response to the glucose load. These data suggest that hyperinsulinemia may play a central role in the development of ovarian hyperandrogenism." @default.
- W194639418 created "2016-06-24" @default.
- W194639418 creator A5015064268 @default.
- W194639418 creator A5037064366 @default.
- W194639418 creator A5045751903 @default.
- W194639418 creator A5046189130 @default.
- W194639418 date "1988-08-01" @default.
- W194639418 modified "2023-09-26" @default.
- W194639418 title "The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism" @default.
- W194639418 cites W115044886 @default.
- W194639418 cites W116138425 @default.
- W194639418 cites W1419813137 @default.
- W194639418 cites W1483604492 @default.
- W194639418 cites W1490352109 @default.
- W194639418 cites W1496236792 @default.
- W194639418 cites W1503163311 @default.
- W194639418 cites W1577942092 @default.
- W194639418 cites W1966700716 @default.
- W194639418 cites W1967260913 @default.
- W194639418 cites W1968513119 @default.
- W194639418 cites W1970610880 @default.
- W194639418 cites W1978197749 @default.
- W194639418 cites W1978611145 @default.
- W194639418 cites W1978681680 @default.
- W194639418 cites W1978998297 @default.
- W194639418 cites W1979958276 @default.
- W194639418 cites W1980354116 @default.
- W194639418 cites W1981168536 @default.
- W194639418 cites W1982445799 @default.
- W194639418 cites W1983097922 @default.
- W194639418 cites W1985065899 @default.
- W194639418 cites W1990147887 @default.
- W194639418 cites W1992878622 @default.
- W194639418 cites W1994360426 @default.
- W194639418 cites W1998426529 @default.
- W194639418 cites W1998538357 @default.
- W194639418 cites W1998630269 @default.
- W194639418 cites W1999061392 @default.
- W194639418 cites W2003902334 @default.
- W194639418 cites W2005307430 @default.
- W194639418 cites W2006053768 @default.
- W194639418 cites W2013731159 @default.
- W194639418 cites W2014855330 @default.
- W194639418 cites W2023712457 @default.
- W194639418 cites W2027550476 @default.
- W194639418 cites W2027960305 @default.
- W194639418 cites W2029538247 @default.
- W194639418 cites W2033662178 @default.
- W194639418 cites W2034007123 @default.
- W194639418 cites W2035004241 @default.
- W194639418 cites W2039564380 @default.
- W194639418 cites W2040471501 @default.
- W194639418 cites W2044232434 @default.
- W194639418 cites W2044426380 @default.
- W194639418 cites W2046500507 @default.
- W194639418 cites W2049512852 @default.
- W194639418 cites W2053065009 @default.
- W194639418 cites W2053222301 @default.
- W194639418 cites W2053337985 @default.
- W194639418 cites W2055659588 @default.
- W194639418 cites W2055722545 @default.
- W194639418 cites W2058093854 @default.
- W194639418 cites W2060261663 @default.
- W194639418 cites W2061782885 @default.
- W194639418 cites W2064143069 @default.
- W194639418 cites W2065631591 @default.
- W194639418 cites W2069521192 @default.
- W194639418 cites W2071946839 @default.
- W194639418 cites W2074269777 @default.
- W194639418 cites W2082073461 @default.
- W194639418 cites W2082182989 @default.
- W194639418 cites W2084962069 @default.
- W194639418 cites W2087286513 @default.
- W194639418 cites W2099469230 @default.
- W194639418 cites W2104120415 @default.
- W194639418 cites W2106120749 @default.
- W194639418 cites W2115093786 @default.
- W194639418 cites W2115700824 @default.
- W194639418 cites W2121497355 @default.
- W194639418 cites W2138910558 @default.
- W194639418 cites W2144027616 @default.
- W194639418 cites W2155995048 @default.
- W194639418 cites W2156941823 @default.
- W194639418 cites W2160972227 @default.
- W194639418 cites W2163235578 @default.
- W194639418 cites W2165047605 @default.
- W194639418 cites W2168419950 @default.
- W194639418 cites W2198261718 @default.
- W194639418 cites W2336164464 @default.
- W194639418 cites W2339120365 @default.
- W194639418 cites W2340100375 @default.
- W194639418 cites W2340428096 @default.
- W194639418 cites W2346202365 @default.
- W194639418 cites W2368309269 @default.
- W194639418 cites W2396953888 @default.
- W194639418 cites W2404434717 @default.
- W194639418 cites W2409392309 @default.
- W194639418 cites W2415521637 @default.