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- W1946395420 abstract "MicroRNAs (miRNAs) play an essential role in the tumorigenesis of gastric carcinoma (GC). MiR-429 has been recently reported to inhibit GC growth; however, whether miR-429 may also regulate the invasion of GC cells is unknown. Here, we showed that miR-429 levels were significantly decreased and ZEB1 and ZEB2 levels were significantly increased in GC specimens, compared to the paired adjacent non-tumor gastric tissue. Moreover, the levels of miR-429 and ZEB1 or ZEB2 inversely correlated in GC specimens. Bioinformatics analyses showed that miR-429 targeted the 3′-untranslated region of both ZEB1 and ZEB2 mRNA to inhibit their translation, which was confirmed by luciferase reporter assay. Overexpression of miR-429 inhibited ZEB1/2-mediated cell invasiveness, while depletion of miR-429 augmented it. Together, our data suggest that miR-429 suppression in GC promotes ZEB1/2-mediated cancer cell invasion." @default.
- W1946395420 created "2016-06-24" @default.
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- W1946395420 date "2015-10-15" @default.
- W1946395420 modified "2023-10-18" @default.
- W1946395420 title "MiR-429 regulates gastric cancer cell invasiveness through ZEB proteins" @default.
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- W1946395420 doi "https://doi.org/10.1007/s13277-015-4094-7" @default.
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