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- W1946397310 abstract "Development of multiple primary tumors is a hallmark of hereditary cancer. At least 1/10 of breast cancers and colorectal cancers occur because of heredity and recently the cell cycle kinase 2, CHEK2 1100delC allele has been identified at a particularly high frequency in families with hereditary breast and colorectal cancer.We utilized the Southern Sweden population-based cancer registry to identify women with double primary breast and colorectal cancer and sequenced tumor material in order to assess the contribution of the CHEK2 1100delC to the development of such metachronous tumors.Among the 75 patients successfully analyzed, 2 (2.5%) carried the CHEK2 1100delC allele. which was not significantly different (p = 0.26) from the 1% (3/300) carriers identified in the control group.In summary, our data suggest that the CHEK2 1100delC is not a major cause of double primary breast and colorectal cancer in Sweden, which suggests that this patient group should not routinely be screened for the CHEK2 1100delC variant." @default.
- W1946397310 created "2016-06-24" @default.
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- W1946397310 date "2006-03-15" @default.
- W1946397310 modified "2023-09-25" @default.
- W1946397310 title "CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum" @default.
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- W1946397310 doi "https://doi.org/10.1186/1471-2407-6-64" @default.
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