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• W1946509370 abstract "Neutrophil cell responses and signal pathways elicited by the chemotactic arachidonic acid metabolites (6E, 8Z, 11Z, 14Z)-5-oxo-icosatetraenoic acid and (6E, 8Z, 11Z, 13E)-5-oxo-15-hydroxy-icosatetraenoic acid were studied and compared with those of other chemotaxins. Polyphosphoinositol lipid analysis revealed activation of phosphatidylinositol-biphosphate 3-kinase by both agonists. Experiments with Fura-2 in the presence of EGTA indicated Ca2+ mobilization from intracellular stores by both 5-oxo-icosanoids. A transient actin response and production of small amounts of superoxide anions upon stimulation with both agents was detected. The changes induced by 5-oxo-icosanoids were more moderate and transient than those obtained by other chemotaxins. Desensitization studies indicated cross-desensitization between both 5-oxo-icosanoids, but no interference with the response of other chemotaxins. All cell responses elicited by 5-oxo-icosanoids at concentrations 500-fold higher than the ED50 of other functions did not induce up-regulation of CD11b and N-formyl-peptide receptors at the cell surface, and failed to potentiate N-formyl-peptide-induced superoxide anion production. These results indicate that 5-oxo-icosanoids trigger a unique pattern of neutrophil responses." @default.
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• W1946509370 date "1996-03-01" @default.
• W1946509370 modified "2023-10-02" @default.
• W1946509370 title "Chemotactic 5-Oxo-Icosatetraenoic Acids Activate A Unique Pattern of Neutrophil Responses. Analysis of Phospholipid Metabolism, Intracellular Ca2+ Transients, Actin Reorganization, Superoxide-Anion Production and Receptor Up-Regulation" @default.
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• W1946509370 doi "https://doi.org/10.1111/j.1432-1033.1996.01003.x" @default.
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