FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1946553623> ?p ?o ?g. }

• W1946553623 startingPage "108" @default.
• W1946553623 abstract "Inositide-dependent signalling pathways regulated by phosphoinositide-specific phospholi- pase C (PI-PLC) beta1 have been demonstrated to play important roles in MDS pathogenesis and in cell differentiation (1). Moreover, the MDS therapy aims at inducing myeloid and/or erythroid differentiation of MDS stem cells. Indeed, azacitidine is a demethylating agent that can induce myeloid differentiation. On the other hand, lenalidomide may restore a normal erythropoiesis. The exact molecular mechanisms underlying the effect of azacitidine and lenalidomide in MDS cells are still unclear, although it is clear that these therapies regulate stem cell proliferation, differentiation and apoptosis (2). The combination of azacitidine and lenalidomide in MDS therapy is now under considera- tion, given the capability of both drugs to balance proliferation and differentiation processes (3). In this study we analyzed the molecular effect of this combination therapy on PI-PLC isoenzymes, not only studying PI-PLCbeta1, but also PI-PLCgamma1, that can be associated with erythropoiesis. We analyzed 44 patients diagnosed with high-risk MDS who were given azacitidine and lenalidomide. Given the limited number of cells, we quantified the expression of these molecules by Real-Time PCR analyses and immunocytochemical experiments. Moreover, we carried out cell cycle analyses and studied both PI-PLCbeta1 methylation status and the expression of Globin genes. In our case series, 28/44 patients were evaluable, with an overall response rate of 78.6% (22/28 cases). At a molecular level, a significant increase of PI-PLCbeta1 and/or PI-PLCgamma1 expression was associated with a favourable clinical response to the combination therapy. Responder cases also showed an increase of Beta-globin expression, hinting at a specific contri- bution of lenalidomide on erythroid activation, whilst the frequent demethylation of PI-PLCbeta1 promoter could be specifically linked to azacitidine. Taken together, our results show that the combination of azacitidine and lenalidomide can be important for activating PI-PLC isoenzymes, therefore regulating myeloid and erythroid dif- ferentiation in MDS cells." @default.
• W1946553623 created "2016-06-24" @default.
• W1946553623 creator A5011060795 @default.
• W1946553623 creator A5033434550 @default.
• W1946553623 creator A5035912933 @default.
• W1946553623 creator A5041169177 @default.
• W1946553623 creator A5042328462 @default.
• W1946553623 creator A5055240267 @default.
• W1946553623 creator A5067996122 @default.
• W1946553623 creator A5070851212 @default.
• W1946553623 creator A5086068112 @default.
• W1946553623 date "2015-01-01" @default.
• W1946553623 modified "2023-09-28" @default.
• W1946553623 title "Differential activation of nuclear inositide-dependent signalling pathways during erythropoiesis and myelopoiesis induced by lenalidomide and azacitidine in myelodysplastic syndromes (MDS)" @default.
• W1946553623 cites W1799359705 @default.
• W1946553623 cites W1976052439 @default.
• W1946553623 cites W2129557378 @default.
• W1946553623 doi "https://doi.org/10.13128/ijae-16969" @default.
• W1946553623 hasPublicationYear "2015" @default.
• W1946553623 type Work @default.
• W1946553623 sameAs 1946553623 @default.
• W1946553623 citedByCount "0" @default.
• W1946553623 crossrefType "journal-article" @default.
• W1946553623 hasAuthorship W1946553623A5011060795 @default.
• W1946553623 hasAuthorship W1946553623A5033434550 @default.
• W1946553623 hasAuthorship W1946553623A5035912933 @default.
• W1946553623 hasAuthorship W1946553623A5041169177 @default.
• W1946553623 hasAuthorship W1946553623A5042328462 @default.
• W1946553623 hasAuthorship W1946553623A5055240267 @default.
• W1946553623 hasAuthorship W1946553623A5067996122 @default.
• W1946553623 hasAuthorship W1946553623A5070851212 @default.
• W1946553623 hasAuthorship W1946553623A5086068112 @default.
• W1946553623 hasConcept C104317684 @default.
• W1946553623 hasConcept C109159458 @default.
• W1946553623 hasConcept C126322002 @default.
• W1946553623 hasConcept C150194340 @default.
• W1946553623 hasConcept C190283241 @default.
• W1946553623 hasConcept C190727270 @default.
• W1946553623 hasConcept C203014093 @default.
• W1946553623 hasConcept C2776063141 @default.
• W1946553623 hasConcept C2776239401 @default.
• W1946553623 hasConcept C2776364478 @default.
• W1946553623 hasConcept C2778248108 @default.
• W1946553623 hasConcept C2779277951 @default.
• W1946553623 hasConcept C2779282312 @default.
• W1946553623 hasConcept C2779703530 @default.
• W1946553623 hasConcept C2780007613 @default.
• W1946553623 hasConcept C2780235182 @default.
• W1946553623 hasConcept C2780817109 @default.
• W1946553623 hasConcept C28328180 @default.
• W1946553623 hasConcept C29537977 @default.
• W1946553623 hasConcept C502942594 @default.
• W1946553623 hasConcept C55493867 @default.
• W1946553623 hasConcept C71924100 @default.
• W1946553623 hasConcept C86803240 @default.
• W1946553623 hasConcept C95444343 @default.
• W1946553623 hasConcept C95862172 @default.
• W1946553623 hasConceptScore W1946553623C104317684 @default.
• W1946553623 hasConceptScore W1946553623C109159458 @default.
• W1946553623 hasConceptScore W1946553623C126322002 @default.
• W1946553623 hasConceptScore W1946553623C150194340 @default.
• W1946553623 hasConceptScore W1946553623C190283241 @default.
• W1946553623 hasConceptScore W1946553623C190727270 @default.
• W1946553623 hasConceptScore W1946553623C203014093 @default.
• W1946553623 hasConceptScore W1946553623C2776063141 @default.
• W1946553623 hasConceptScore W1946553623C2776239401 @default.
• W1946553623 hasConceptScore W1946553623C2776364478 @default.
• W1946553623 hasConceptScore W1946553623C2778248108 @default.
• W1946553623 hasConceptScore W1946553623C2779277951 @default.
• W1946553623 hasConceptScore W1946553623C2779282312 @default.
• W1946553623 hasConceptScore W1946553623C2779703530 @default.
• W1946553623 hasConceptScore W1946553623C2780007613 @default.
• W1946553623 hasConceptScore W1946553623C2780235182 @default.
• W1946553623 hasConceptScore W1946553623C2780817109 @default.
• W1946553623 hasConceptScore W1946553623C28328180 @default.
• W1946553623 hasConceptScore W1946553623C29537977 @default.
• W1946553623 hasConceptScore W1946553623C502942594 @default.
• W1946553623 hasConceptScore W1946553623C55493867 @default.
• W1946553623 hasConceptScore W1946553623C71924100 @default.
• W1946553623 hasConceptScore W1946553623C86803240 @default.
• W1946553623 hasConceptScore W1946553623C95444343 @default.
• W1946553623 hasConceptScore W1946553623C95862172 @default.
• W1946553623 hasIssue "1" @default.
• W1946553623 hasLocation W19465536231 @default.
• W1946553623 hasOpenAccess W1946553623 @default.
• W1946553623 hasPrimaryLocation W19465536231 @default.
• W1946553623 hasRelatedWork W1480336412 @default.
• W1946553623 hasRelatedWork W1967536071 @default.
• W1946553623 hasRelatedWork W2046450591 @default.
• W1946553623 hasRelatedWork W2049560078 @default.
• W1946553623 hasRelatedWork W2080204022 @default.
• W1946553623 hasRelatedWork W2085686347 @default.
• W1946553623 hasRelatedWork W2092213185 @default.
• W1946553623 hasRelatedWork W2142106028 @default.
• W1946553623 hasRelatedWork W2161219324 @default.
• W1946553623 hasRelatedWork W2163586985 @default.
• W1946553623 hasRelatedWork W2189137086 @default.
• W1946553623 hasRelatedWork W2335173270 @default.
• W1946553623 hasRelatedWork W2509147643 @default.

• next