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• W1946602712 abstract "BackgroundMany patients with acute exacerbation of asthma are non-responders to inhaled β-adrenergic agonists. The goal of this study was to evaluate the safety and efficacy of intravenous bedoradrine (MN-221), a highly selective β2-adrenergic agonist, as adjunct to standard therapy in the management of patients with acute exacerbation of asthma who did not respond to standard therapy.MethodsPatients (N = 167) received standard therapy and were randomized to either bedoradrine (1200 μg) or placebo. Safety and efficacy parameters were monitored hourly for 3 h, followed by a 24-h follow-up visit and an 8-day follow-up phone call. Change in %FEV1 from baseline to Hour 3 was the primary outcome. Secondary outcome measures included change in %FEV1 at 1 and 2 h, change in dyspnea score at 1, 2, and 3 h, treatment failure rate, defined as a combination of hospitalization on the index visit or return to the emergency department within 1 week, and safety monitoring.ResultsThere was no significant difference in %FEV1 at 3 h between the 2 groups. The dyspnea scores were significantly improved for patients treated with bedoradrine compared to placebo (AUC0–2 h P < 0.005, AUC0–3 h P < 0.05). The safety profile for those treated with bedoradrine was consistent with the known mechanism of action of β-adrenergic agonists, and included both cardiovascular and metabolic effects.ConclusionsIntravenous bedoradrine, in addition to standard therapy, did not significantly increase %FEV1 at 3 h, but it was associated with significantly improved dyspnea scores.Trial registrationClinicaltrials.gov; study name: MN-221-CL-007, registration number: NCT00838591; www.clinical trials.gov" @default.
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• W1946602712 date "2015-10-01" @default.
• W1946602712 modified "2023-10-03" @default.
• W1946602712 title "Efficacy of a new intravenous β 2 -adrenergic agonist (bedoradrine, MN-221) for patients with an acute exacerbation of asthma" @default.
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• W1946602712 doi "https://doi.org/10.1016/j.rmed.2015.08.003" @default.
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