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- W1946623717 abstract "Cell migration is an essential process involved in the development and maintenance of multicellular organisms. Electric fields (EFs) are one of the many physical and chemical factors known to affect cell migration, a phenomenon termed electrotaxis or galvanotaxis. In this paper, a microfluidics chip was developed to study the migration of cells under different electrical and chemical stimuli. This chip is capable of providing four different strengths of EFs in combination with two different chemicals via one simple set of agar salt bridges and Ag/AgCl electrodes. NIH 3T3 fibroblasts were seeded inside this chip to study their migration and reactive oxygen species (ROS) production in response to different EF strengths and the presence of β-lapachone. We found that both the EF and β-lapachone level increased the cell migration rate and the production of ROS in an EF-strength-dependent manner. A strong linear correlation between the cell migration rate and the amount of intracellular ROS suggests that ROS are an intermediate product by which EF and β-lapachone enhance cell migration. Moreover, an anti-oxidant, α-tocopherol, was found to quench the production of ROS, resulting in a decrease in the migration rate." @default.
- W1946623717 created "2016-06-24" @default.
- W1946623717 creator A5000765778 @default.
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- W1946623717 creator A5072013895 @default.
- W1946623717 creator A5080311508 @default.
- W1946623717 creator A5082744858 @default.
- W1946623717 date "2015-09-01" @default.
- W1946623717 modified "2023-10-14" @default.
- W1946623717 title "Correlation between cell migration and reactive oxygen species under electric field stimulation" @default.
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- W1946623717 doi "https://doi.org/10.1063/1.4932662" @default.
- W1946623717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4600077" @default.
- W1946623717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26487906" @default.
- W1946623717 hasPublicationYear "2015" @default.
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