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- W194667063 abstract "Publisher Summary This chapter describes the medullary carcinoma of the thyroid (MCT). The MCT constitutes some 10–12% of all thyroid malignancies. The MCT is generally regarded as more aggressive than papillary and follicular carcinoma of the thyroid. In three large series of patients with MCT, the 5-year survival ranged from 48% to 55%. However, there is great variability in survival after diagnosis varying from only a few months to more than 30 years. Such wide-ranging differences in outcome even occur within closely related families. The age range at presentation is very wide, ranging from 2 years to more than 50 years of age, although the majority tends to be between 25 and 45 years old. Even when the primary lesion is less than 1 mm in size, there may be metastases in cervical and mediastinal lymph nodes in up to 50% of cases. Blood-borne spread is late and tends to be to the lungs, and liver metastases have been found in up to a quarter of patients in some series. The sporadic form of MCT usually presents as a solid cold thyroid nodule diagnosed either from the operative specimen or from an elevated preoperative serum calcitonin." @default.
- W194667063 created "2016-06-24" @default.
- W194667063 creator A5059006569 @default.
- W194667063 date "1993-01-01" @default.
- W194667063 modified "2023-09-25" @default.
- W194667063 title "Medullary Carcinoma of the Thyroid" @default.
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- W194667063 doi "https://doi.org/10.1016/b978-0-7506-1390-3.50027-1" @default.
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