FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1946670893> ?p ?o ?g. }

• W1946670893 endingPage "377" @default.
• W1946670893 startingPage "366" @default.
• W1946670893 abstract "Membrane‐type 1 matrix metalloproteinase (MT1‐MMP, MMP‐14), a transmembrane proteinase with an extracellular catalytic domain and a short cytoplasmic tail, degrades extracellular matrix components and controls diverse cell functions through proteolytic and non‐proteolytic interactions with extracellular, intracellular, and transmembrane proteins. Here we show that in tumor cells MT1‐MMP downregulates fibroblast growth factor‐2 (FGF‐2) signaling by reducing the amount of FGF‐2 bound to the cell surface with high and low affinity. FGF‐2 induces weaker activation of ERK1/2 MAP kinase in MT1‐MMP expressing cells than in cells devoid of MT1‐MMP. This effect is abolished in cells that express proteolytically inactive MT1‐MMP but persists in cells expressing MT1‐MMP mutants devoid of hemopexin‐like or cytoplasmic domain, showing that FGF‐2 signaling is downregulated by MT1‐MMP proteolytic activity. MT1‐MMP expression results in downregulation of FGFR‐1 and ‐4, and in decreased amount of cell surface‐associated FGF‐2. In addition, MT1‐MMP strongly reduces the amount of FGF‐2 bound to the cell surface with low affinity. Because FGF‐2 association with low‐affinity binding sites is a prerequisite for binding to its high‐affinity receptors, downregulation of low‐affinity binding to the cell surface results in decreased FGF‐2 signaling. Consistent with this conclusion, FGF‐2 induction of tumor cell migration and invasion in vitro is stronger in cells devoid of MT1‐ MMP than in MT1‐MMP expressing cells. Thus, MT1‐MMP controls FGF‐2 signaling by a proteolytic mechanism that decreases the cell's biological response to FGF‐2. J. Cell. Physiol. 230: 366–377, 2015. © 2014 Wiley Periodicals, Inc." @default.
• W1946670893 created "2016-06-24" @default.
• W1946670893 creator A5019808217 @default.
• W1946670893 creator A5058196857 @default.
• W1946670893 creator A5091290141 @default.
• W1946670893 date "2014-10-28" @default.
• W1946670893 modified "2023-10-09" @default.
• W1946670893 title "Membrane‐Type 1 Matrix Metalloproteinase Downregulates Fibroblast Growth Factor‐2 Binding to the Cell Surface and Intracellular Signaling" @default.
• W1946670893 cites W1630290269 @default.
• W1946670893 cites W1963805383 @default.
• W1946670893 cites W1963818935 @default.
• W1946670893 cites W1965358479 @default.
• W1946670893 cites W1965938746 @default.
• W1946670893 cites W1968084778 @default.
• W1946670893 cites W1970922431 @default.
• W1946670893 cites W1974194840 @default.
• W1946670893 cites W1975749015 @default.
• W1946670893 cites W1977803215 @default.
• W1946670893 cites W1980638845 @default.
• W1946670893 cites W1992885568 @default.
• W1946670893 cites W1996360865 @default.
• W1946670893 cites W1998863388 @default.
• W1946670893 cites W2000946071 @default.
• W1946670893 cites W2008980811 @default.
• W1946670893 cites W2016484384 @default.
• W1946670893 cites W2022512688 @default.
• W1946670893 cites W2027239974 @default.
• W1946670893 cites W2027310148 @default.
• W1946670893 cites W2029116391 @default.
• W1946670893 cites W2030155901 @default.
• W1946670893 cites W2034559265 @default.
• W1946670893 cites W2048216957 @default.
• W1946670893 cites W2053811100 @default.
• W1946670893 cites W2063897047 @default.
• W1946670893 cites W2070312129 @default.
• W1946670893 cites W2072162018 @default.
• W1946670893 cites W2075819331 @default.
• W1946670893 cites W2076415360 @default.
• W1946670893 cites W2080062167 @default.
• W1946670893 cites W2087932661 @default.
• W1946670893 cites W2089726534 @default.
• W1946670893 cites W2096372265 @default.
• W1946670893 cites W2098466520 @default.
• W1946670893 cites W2100592123 @default.
• W1946670893 cites W2102174623 @default.
• W1946670893 cites W2107444537 @default.
• W1946670893 cites W2108174762 @default.
• W1946670893 cites W2115810495 @default.
• W1946670893 cites W2121164372 @default.
• W1946670893 cites W2125886792 @default.
• W1946670893 cites W2126527231 @default.
• W1946670893 cites W2126737266 @default.
• W1946670893 cites W2140563259 @default.
• W1946670893 cites W2141592196 @default.
• W1946670893 cites W2146151086 @default.
• W1946670893 cites W2155880350 @default.
• W1946670893 cites W2167544720 @default.
• W1946670893 cites W2169147580 @default.
• W1946670893 cites W2171597870 @default.
• W1946670893 cites W4236861583 @default.
• W1946670893 doi "https://doi.org/10.1002/jcp.24717" @default.
• W1946670893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4281515" @default.
• W1946670893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24986796" @default.
• W1946670893 hasPublicationYear "2014" @default.
• W1946670893 type Work @default.
• W1946670893 sameAs 1946670893 @default.
• W1946670893 citedByCount "12" @default.
• W1946670893 countsByYear W19466708932015 @default.
• W1946670893 countsByYear W19466708932016 @default.
• W1946670893 countsByYear W19466708932017 @default.
• W1946670893 countsByYear W19466708932018 @default.
• W1946670893 countsByYear W19466708932020 @default.
• W1946670893 countsByYear W19466708932021 @default.
• W1946670893 countsByYear W19466708932022 @default.
• W1946670893 countsByYear W19466708932023 @default.
• W1946670893 crossrefType "journal-article" @default.
• W1946670893 hasAuthorship W1946670893A5019808217 @default.
• W1946670893 hasAuthorship W1946670893A5058196857 @default.
• W1946670893 hasAuthorship W1946670893A5091290141 @default.
• W1946670893 hasBestOaLocation W19466708932 @default.
• W1946670893 hasConcept C104317684 @default.
• W1946670893 hasConcept C109523444 @default.
• W1946670893 hasConcept C127561419 @default.
• W1946670893 hasConcept C1491633281 @default.
• W1946670893 hasConcept C170493617 @default.
• W1946670893 hasConcept C185592680 @default.
• W1946670893 hasConcept C189165786 @default.
• W1946670893 hasConcept C190062978 @default.
• W1946670893 hasConcept C197462201 @default.
• W1946670893 hasConcept C202751555 @default.
• W1946670893 hasConcept C24530287 @default.
• W1946670893 hasConcept C2776746612 @default.
• W1946670893 hasConcept C2778106830 @default.
• W1946670893 hasConcept C2780381497 @default.
• W1946670893 hasConcept C28406088 @default.
• W1946670893 hasConcept C54009773 @default.
• W1946670893 hasConcept C54355233 @default.
• W1946670893 hasConcept C55493867 @default.

• next