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- W194668813 abstract "Abstract T cell receptor (TCR) signaling plays a critical role in T cell development, activation of conventional T cells, and induction of suppressive function of regulatory T cells (Treg). Abnormal TCR signaling can skew the T cell repertoire, induce dysregulated T cell activation, and lead to autoimmune diseases. How TCR signals control intrathymic T cell development, T cell activation, and Treg function is still not fully understood. Diacylglycerol (DAG) kinases (DGKs) are a family of enzymes that catalyze the conversion of DAG to phosphatidic acid (PA) through phosphorylation. Both DAG and PA are second messengers involved in signaling from many receptors and both are generated following TCR stimulation. DAG and PA exert their activities by associating with and modulating the activities and subcellular localizations of numerous effector molecules. In T cells, both alpha and zeta isoforms of the DGK family are expressed. We have recently demonstrated that DGKalpha and zeta negatively regulate T cell activation, and that deficiency of either DGKalpha or zeta results in T cells that are hyper-responsive to TCR stimulation and resistant to anergy induction. Our current studies using DGKalpha and zeta doubly deficient mice have further demonstrated that these two DGK isoforms synergistically regulate thymic selection, T cell homeostasis, and Treg function to prevent autoimmune disease." @default.
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- W194668813 date "2007-04-01" @default.
- W194668813 modified "2023-10-16" @default.
- W194668813 title "Synergistic control of T cell activation, regulatory T cell function, and autoimmunity by Diacylglycerol Kinases alpha and zeta (128.26)" @default.
- W194668813 doi "https://doi.org/10.4049/jimmunol.178.supp.128.26" @default.
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