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• W1946753601 abstract "Stimuli-responsive gene delivery systems maximize therapeutic efficacy by controlling the cytosolic conveyance and rate of effective gene release. We present herein a hybrid nanocomposite composed of a 2D nanomaterial, MoS2, modified by attaching two polymers (polyethylenimine (PEI) and polyethylenglycol (PEG)) via disulfide bonds. This MoS2-PEI-PEG nanocomposite interacts with DNA by electrostatic interaction, and accordingly forms a nanosized complex with high stability. Photothermal conversion of MoS2 nanosheet is employed in order to induce photothermally triggered endosomal escape upon the near infrared light irradiation. After endosomal escape, polymers are detached from the MoS2 nanosheet by the intracellular reducing agent, glutathione (GSH), resulting in effective gene release from the nanocomposite. This sequential process initiated by external and internal stimuli remarkably enhances gene delivery efficiency by effective endosomal escape and gene release without severe cytotoxicity. Our rationally designed MoS2 nanocomposite provides a spatiotemporally controllable platform to deliver genetic material into cells." @default.
• W1946753601 created "2016-06-24" @default.
• W1946753601 creator A5003478304 @default.
• W1946753601 creator A5008383067 @default.
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• W1946753601 date "2015-09-21" @default.
• W1946753601 modified "2023-09-24" @default.
• W1946753601 title "Single-Layered MoS₂ -PEI-PEG Nanocomposite-Mediated Gene Delivery Controlled by Photo and Redox Stimuli" @default.
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• W1946753601 doi "https://doi.org/10.1002/smll.201501655" @default.
• W1946753601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26389712" @default.
• W1946753601 hasPublicationYear "2015" @default.
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