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- W1946883496 abstract "Parkinson's disease (PD) has long been considered predominantly to be a movement disorder, and it is only relatively recently that nonmotor symptoms of PD have been recognized to be a major concern to patients. Consequently, there has been surprisingly little investigation into the feasibility of utilizing cell replacement therapies to ameliorate any of the nonmotor dysfunctions of PD. In this chapter, we identify nonmotor impairments associated predominately with dopaminergic dysmodulation, evaluate the few emerging studies that have identified a role for dopamine and nigral transplantation in nonmotor performance, and consider a number of outstanding questions and considerations dominating the field of nigral transplantation today. Preliminary results obtained from rodent models of PD, despite being limited in number, give clear indications of graft effects on striatal processing beyond the simple activation of motor output and promise a major, exciting, and fruitful new avenue of research for the next decade. We can now consider the prospect of rewriting the opportunities for treating patients, with new stem cell sources to be complemented by new targets for therapeutic benefit." @default.
- W1946883496 created "2016-06-24" @default.
- W1946883496 creator A5024476885 @default.
- W1946883496 creator A5039606775 @default.
- W1946883496 creator A5057611378 @default.
- W1946883496 date "2012-01-01" @default.
- W1946883496 modified "2023-09-30" @default.
- W1946883496 title "Nigral grafts in animal models of Parkinson's disease. Is recovery beyond motor function possible?" @default.
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