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- W1947180815 endingPage "561" @default.
- W1947180815 startingPage "547" @default.
- W1947180815 abstract "Understanding how genetic novelties arise is a central goal of evolutionary biology. To this end, programmed DNA elimination and RNA splicing deserve special consideration. While programmed DNA elimination reshapes genomes by eliminating chromatin during organismal development, RNA splicing rearranges genetic messages by removing intronic regions during transcription. Small RNAs help to mediate this class of sequence reorganization, which is not error-free. It is this imperfection that makes programmed DNA elimination and RNA splicing excellent candidates for generating evolutionary novelties. Leveraging a number of these two processes' mechanistic and evolutionary properties, which have been uncovered over the past years, we present recently proposed models and empirical evidence for how splicing can shape the structure of protein-coding genes in eukaryotes. We also chronicle a number of intriguing similarities between the processes of programmed DNA elimination and RNA splicing, and highlight the role that the variation in the population-genetic environment may play in shaping their target sequences." @default.
- W1947180815 created "2016-06-24" @default.
- W1947180815 creator A5028146415 @default.
- W1947180815 creator A5072959279 @default.
- W1947180815 date "2015-07-03" @default.
- W1947180815 modified "2023-09-27" @default.
- W1947180815 title "On the path to genetic novelties: insights from programmed DNA elimination and RNA splicing" @default.
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