Matches in SemOpenAlex for { <https://semopenalex.org/work/W194772009> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W194772009 endingPage "40" @default.
- W194772009 startingPage "322" @default.
- W194772009 abstract "In unasthetized dogs naloxone induced effects opposed to those of morphine (tachycardia, agitation, hyperthermia, tachypnea) and mydriasis. These effects were moderate and transient; some of them were elicited with low doses being border-line after 0.03 mg.kg-1 s.c., statistically significant after 0.1 mg.kg-1 s.c.; they increased slightly with the dose. After repeated administrations, acute tolerance developed and some moderate morphine-like effects (miosis, sedation) were observed. The stimulatory effects described here may result from antagonism of a morphinomimetic natural ligand,and represent thus indirect arguments in favour of normal functions of this ligand; these functions would be to temper not only algesic but also other stimulant reactions. The limitation of the effects might result from the limited release of this ligand in normal dogs and (or) from interfering morphinomimetic properties of naloxone, which are apparently unmasked when administrations are repeated. Both, stimulatory and inhibitory effects of naloxone are not liable to represent noticeable side-effects of this drug, but they both might play some role in the mechanisms of precipitated abstinence." @default.
- W194772009 created "2016-06-24" @default.
- W194772009 creator A5029242243 @default.
- W194772009 creator A5052238438 @default.
- W194772009 date "1976-08-01" @default.
- W194772009 modified "2023-09-23" @default.
- W194772009 title "[Reversal by naloxone of the effects of morphine on the unanesthetized dog]." @default.
- W194772009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/984983" @default.
- W194772009 hasPublicationYear "1976" @default.
- W194772009 type Work @default.
- W194772009 sameAs 194772009 @default.
- W194772009 citedByCount "7" @default.
- W194772009 countsByYear W1947720092015 @default.
- W194772009 crossrefType "journal-article" @default.
- W194772009 hasAuthorship W194772009A5029242243 @default.
- W194772009 hasAuthorship W194772009A5052238438 @default.
- W194772009 hasConcept C118552586 @default.
- W194772009 hasConcept C126322002 @default.
- W194772009 hasConcept C170493617 @default.
- W194772009 hasConcept C2777389121 @default.
- W194772009 hasConcept C2777724181 @default.
- W194772009 hasConcept C2778312941 @default.
- W194772009 hasConcept C2778750930 @default.
- W194772009 hasConcept C2779109636 @default.
- W194772009 hasConcept C2780283014 @default.
- W194772009 hasConcept C2780557958 @default.
- W194772009 hasConcept C2780687700 @default.
- W194772009 hasConcept C2781063702 @default.
- W194772009 hasConcept C42219234 @default.
- W194772009 hasConcept C71924100 @default.
- W194772009 hasConcept C98274493 @default.
- W194772009 hasConceptScore W194772009C118552586 @default.
- W194772009 hasConceptScore W194772009C126322002 @default.
- W194772009 hasConceptScore W194772009C170493617 @default.
- W194772009 hasConceptScore W194772009C2777389121 @default.
- W194772009 hasConceptScore W194772009C2777724181 @default.
- W194772009 hasConceptScore W194772009C2778312941 @default.
- W194772009 hasConceptScore W194772009C2778750930 @default.
- W194772009 hasConceptScore W194772009C2779109636 @default.
- W194772009 hasConceptScore W194772009C2780283014 @default.
- W194772009 hasConceptScore W194772009C2780557958 @default.
- W194772009 hasConceptScore W194772009C2780687700 @default.
- W194772009 hasConceptScore W194772009C2781063702 @default.
- W194772009 hasConceptScore W194772009C42219234 @default.
- W194772009 hasConceptScore W194772009C71924100 @default.
- W194772009 hasConceptScore W194772009C98274493 @default.
- W194772009 hasIssue "2" @default.
- W194772009 hasLocation W1947720091 @default.
- W194772009 hasOpenAccess W194772009 @default.
- W194772009 hasPrimaryLocation W1947720091 @default.
- W194772009 hasRelatedWork W194772009 @default.
- W194772009 hasRelatedWork W1964996891 @default.
- W194772009 hasRelatedWork W2006934195 @default.
- W194772009 hasRelatedWork W2008206320 @default.
- W194772009 hasRelatedWork W2008673496 @default.
- W194772009 hasRelatedWork W2023375760 @default.
- W194772009 hasRelatedWork W2031419138 @default.
- W194772009 hasRelatedWork W2037334482 @default.
- W194772009 hasRelatedWork W2048107676 @default.
- W194772009 hasRelatedWork W2112642895 @default.
- W194772009 hasVolume "222" @default.
- W194772009 isParatext "false" @default.
- W194772009 isRetracted "false" @default.
- W194772009 magId "194772009" @default.
- W194772009 workType "article" @default.