FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1947991388> ?p ?o ?g. }

• W1947991388 endingPage "4832" @default.
• W1947991388 startingPage "4826" @default.
• W1947991388 abstract "Abstract It is clear that the development of an autoimmune disease usually depends on both a genetic predisposition and an environmental trigger. In this study, we demonstrate that BALB/c mice develop a lupus-like serology following immunization with a peptide mimetope of DNA, while DBA/2 mice do not. We further demonstrate that the critical difference resides within the B cell compartment and that the naive B cell repertoire of DBA/2 mice has fewer B cells specific for the DNA mimetope. Differences in the strength of B cell receptor signaling exist between these two strains and may be responsible for the difference in disease susceptibility. BALB/c mice possess more autoreactive cells in the native repertoire; they display a weaker response to Ag and exhibit less Ag-induced apoptosis of B cells. DBA/2 mice, in contrast, display a stronger B cell receptor signal and more stringent central tolerance. This correlates with resistance to lupus induction. Thus, the degree to which autoreactive B cells have been eliminated from the naive B cell repertoire is genetically regulated and may determine whether a nonspontaneously autoimmune host will develop autoimmunity following exposure to Ag." @default.
• W1947991388 created "2016-06-24" @default.
• W1947991388 creator A5001711556 @default.
• W1947991388 creator A5007474253 @default.
• W1947991388 creator A5061777151 @default.
• W1947991388 creator A5089808423 @default.
• W1947991388 date "2003-05-01" @default.
• W1947991388 modified "2023-10-12" @default.
• W1947991388 title "The Naive B Cell Repertoire Predisposes to Antigen-Induced Systemic Lupus Erythematosus" @default.
• W1947991388 cites W1491010274 @default.
• W1947991388 cites W1527959728 @default.
• W1947991388 cites W1552738427 @default.
• W1947991388 cites W1600894056 @default.
• W1947991388 cites W1625166229 @default.
• W1947991388 cites W1650168614 @default.
• W1947991388 cites W1656526357 @default.
• W1947991388 cites W1749491350 @default.
• W1947991388 cites W1826755587 @default.
• W1947991388 cites W1965830188 @default.
• W1947991388 cites W1966388921 @default.
• W1947991388 cites W1966949480 @default.
• W1947991388 cites W1968166269 @default.
• W1947991388 cites W1968757041 @default.
• W1947991388 cites W1996169398 @default.
• W1947991388 cites W1996486759 @default.
• W1947991388 cites W1997796758 @default.
• W1947991388 cites W2003197794 @default.
• W1947991388 cites W2008193652 @default.
• W1947991388 cites W2009568488 @default.
• W1947991388 cites W2010957725 @default.
• W1947991388 cites W2013136814 @default.
• W1947991388 cites W2016208323 @default.
• W1947991388 cites W2027191266 @default.
• W1947991388 cites W2027874825 @default.
• W1947991388 cites W2034271713 @default.
• W1947991388 cites W2036321057 @default.
• W1947991388 cites W2042797177 @default.
• W1947991388 cites W2050376530 @default.
• W1947991388 cites W2062198339 @default.
• W1947991388 cites W2063661003 @default.
• W1947991388 cites W2066542432 @default.
• W1947991388 cites W2070539334 @default.
• W1947991388 cites W2072877277 @default.
• W1947991388 cites W2073300729 @default.
• W1947991388 cites W2081166326 @default.
• W1947991388 cites W2087653208 @default.
• W1947991388 cites W2098285548 @default.
• W1947991388 cites W2099704507 @default.
• W1947991388 cites W2103982494 @default.
• W1947991388 cites W2113621372 @default.
• W1947991388 cites W2123443961 @default.
• W1947991388 cites W2159553446 @default.
• W1947991388 cites W2163889822 @default.
• W1947991388 cites W2164979183 @default.
• W1947991388 cites W2179862924 @default.
• W1947991388 cites W4238342025 @default.
• W1947991388 cites W4313342387 @default.
• W1947991388 doi "https://doi.org/10.4049/jimmunol.170.9.4826" @default.
• W1947991388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12707365" @default.
• W1947991388 hasPublicationYear "2003" @default.
• W1947991388 type Work @default.
• W1947991388 sameAs 1947991388 @default.
• W1947991388 citedByCount "26" @default.
• W1947991388 countsByYear W19479913882012 @default.
• W1947991388 countsByYear W19479913882013 @default.
• W1947991388 countsByYear W19479913882017 @default.
• W1947991388 countsByYear W19479913882018 @default.
• W1947991388 countsByYear W19479913882021 @default.
• W1947991388 crossrefType "journal-article" @default.
• W1947991388 hasAuthorship W1947991388A5001711556 @default.
• W1947991388 hasAuthorship W1947991388A5007474253 @default.
• W1947991388 hasAuthorship W1947991388A5061777151 @default.
• W1947991388 hasAuthorship W1947991388A5089808423 @default.
• W1947991388 hasBestOaLocation W19479913881 @default.
• W1947991388 hasConcept C121332964 @default.
• W1947991388 hasConcept C142724271 @default.
• W1947991388 hasConcept C147483822 @default.
• W1947991388 hasConcept C157695867 @default.
• W1947991388 hasConcept C159654299 @default.
• W1947991388 hasConcept C19317047 @default.
• W1947991388 hasConcept C200180986 @default.
• W1947991388 hasConcept C203014093 @default.
• W1947991388 hasConcept C24890656 @default.
• W1947991388 hasConcept C2776090121 @default.
• W1947991388 hasConcept C2776912625 @default.
• W1947991388 hasConcept C2778453870 @default.
• W1947991388 hasConcept C2778473898 @default.
• W1947991388 hasConcept C2779075594 @default.
• W1947991388 hasConcept C2779134260 @default.
• W1947991388 hasConcept C2780130043 @default.
• W1947991388 hasConcept C45189115 @default.
• W1947991388 hasConcept C67662055 @default.
• W1947991388 hasConcept C71924100 @default.
• W1947991388 hasConcept C86803240 @default.
• W1947991388 hasConcept C8891405 @default.
• W1947991388 hasConceptScore W1947991388C121332964 @default.
• W1947991388 hasConceptScore W1947991388C142724271 @default.
• W1947991388 hasConceptScore W1947991388C147483822 @default.

• next