Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948045513> ?p ?o ?g. }
- W1948045513 endingPage "543" @default.
- W1948045513 startingPage "532" @default.
- W1948045513 abstract "J. Neurochem. (2011) 119 , 532–543. Abstract The formation and refinement of synaptic connections are key steps of neural development to establish elaborate brain networks. To investigate the functional role of protein tyrosine phosphatase (PTP) σ, we employed an olfactory sensory neuron (OSN)‐specific gene manipulation system in combination with in vivo imaging of transparent zebrafish embryos. Knockdown of PTPσ enhanced the accumulation of synaptic vesicles in the axon terminals of OSNs. The exaggerated accumulation of synaptic vesicles was restored to the normal level by the OSN‐specific expression of PTPσ, indicating that presynaptic PTPσ is responsible for the regulation of synaptic vesicle accumulation. Consistently, transient expression of a dominant‐negative form of PTPσ in OSNs enhanced the accumulation of synaptic vesicles. The exaggerated accumulation of synaptic vesicles was reproduced in transgenic zebrafish lines carrying an OSN‐specific expression vector of the dominant‐negative PTPσ. By electron microscopic analysis of the transgenic line, we found the significant increase of the number of OSN‐mitral cell synapses in the central zone of the olfactory bulb. The density of docked vesicles at the active zone was also increased significantly. Our results suggest that presynaptic PTPσ controls the number of OSN‐mitral cell synapses by suppressing their excessive increase." @default.
- W1948045513 created "2016-06-24" @default.
- W1948045513 creator A5009419922 @default.
- W1948045513 creator A5017708258 @default.
- W1948045513 creator A5046667079 @default.
- W1948045513 creator A5048397528 @default.
- W1948045513 creator A5057492274 @default.
- W1948045513 date "2011-08-29" @default.
- W1948045513 modified "2023-10-16" @default.
- W1948045513 title "Protein tyrosine phosphatase σ regulates the synapse number of zebrafish olfactory sensory neurons" @default.
- W1948045513 cites W136427227 @default.
- W1948045513 cites W1501284479 @default.
- W1948045513 cites W1591639440 @default.
- W1948045513 cites W1880531754 @default.
- W1948045513 cites W1973160416 @default.
- W1948045513 cites W1980059698 @default.
- W1948045513 cites W1981415432 @default.
- W1948045513 cites W1981434287 @default.
- W1948045513 cites W1987428952 @default.
- W1948045513 cites W1988011192 @default.
- W1948045513 cites W1993323334 @default.
- W1948045513 cites W1997955557 @default.
- W1948045513 cites W1998756807 @default.
- W1948045513 cites W2007333101 @default.
- W1948045513 cites W2007466229 @default.
- W1948045513 cites W2032659675 @default.
- W1948045513 cites W2035145219 @default.
- W1948045513 cites W2043617798 @default.
- W1948045513 cites W2048743675 @default.
- W1948045513 cites W2050465941 @default.
- W1948045513 cites W2054017648 @default.
- W1948045513 cites W2056815050 @default.
- W1948045513 cites W2064969847 @default.
- W1948045513 cites W2065274926 @default.
- W1948045513 cites W2072147769 @default.
- W1948045513 cites W2072403951 @default.
- W1948045513 cites W2074258117 @default.
- W1948045513 cites W2080209385 @default.
- W1948045513 cites W2081608180 @default.
- W1948045513 cites W2081850577 @default.
- W1948045513 cites W2119503012 @default.
- W1948045513 cites W2130609073 @default.
- W1948045513 cites W2141413750 @default.
- W1948045513 cites W2144586440 @default.
- W1948045513 cites W2152798081 @default.
- W1948045513 cites W2155870242 @default.
- W1948045513 cites W2161755844 @default.
- W1948045513 cites W2163073537 @default.
- W1948045513 cites W2170893097 @default.
- W1948045513 doi "https://doi.org/10.1111/j.1471-4159.2011.07411.x" @default.
- W1948045513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21812780" @default.
- W1948045513 hasPublicationYear "2011" @default.
- W1948045513 type Work @default.
- W1948045513 sameAs 1948045513 @default.
- W1948045513 citedByCount "9" @default.
- W1948045513 countsByYear W19480455132012 @default.
- W1948045513 countsByYear W19480455132013 @default.
- W1948045513 countsByYear W19480455132014 @default.
- W1948045513 countsByYear W19480455132015 @default.
- W1948045513 countsByYear W19480455132018 @default.
- W1948045513 crossrefType "journal-article" @default.
- W1948045513 hasAuthorship W1948045513A5009419922 @default.
- W1948045513 hasAuthorship W1948045513A5017708258 @default.
- W1948045513 hasAuthorship W1948045513A5046667079 @default.
- W1948045513 hasAuthorship W1948045513A5048397528 @default.
- W1948045513 hasAuthorship W1948045513A5057492274 @default.
- W1948045513 hasBestOaLocation W19480455131 @default.
- W1948045513 hasConcept C104317684 @default.
- W1948045513 hasConcept C127445978 @default.
- W1948045513 hasConcept C130316041 @default.
- W1948045513 hasConcept C148785051 @default.
- W1948045513 hasConcept C169760540 @default.
- W1948045513 hasConcept C187102610 @default.
- W1948045513 hasConcept C2776878037 @default.
- W1948045513 hasConcept C2780496858 @default.
- W1948045513 hasConcept C41625074 @default.
- W1948045513 hasConcept C529278444 @default.
- W1948045513 hasConcept C55493867 @default.
- W1948045513 hasConcept C62478195 @default.
- W1948045513 hasConcept C85528070 @default.
- W1948045513 hasConcept C86803240 @default.
- W1948045513 hasConcept C95444343 @default.
- W1948045513 hasConceptScore W1948045513C104317684 @default.
- W1948045513 hasConceptScore W1948045513C127445978 @default.
- W1948045513 hasConceptScore W1948045513C130316041 @default.
- W1948045513 hasConceptScore W1948045513C148785051 @default.
- W1948045513 hasConceptScore W1948045513C169760540 @default.
- W1948045513 hasConceptScore W1948045513C187102610 @default.
- W1948045513 hasConceptScore W1948045513C2776878037 @default.
- W1948045513 hasConceptScore W1948045513C2780496858 @default.
- W1948045513 hasConceptScore W1948045513C41625074 @default.
- W1948045513 hasConceptScore W1948045513C529278444 @default.
- W1948045513 hasConceptScore W1948045513C55493867 @default.
- W1948045513 hasConceptScore W1948045513C62478195 @default.
- W1948045513 hasConceptScore W1948045513C85528070 @default.
- W1948045513 hasConceptScore W1948045513C86803240 @default.
- W1948045513 hasConceptScore W1948045513C95444343 @default.
- W1948045513 hasIssue "3" @default.