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• W1948200758 abstract "Serotonin (5-HT) has been strongly implicated in the regulation of the mammalian circadian clock located in the suprachiasmatic nuclei (SCN). However, little is known of the pattern of neuronal 5-HT release in the SCN or of the factors involved in regulating its release. Using in vivo microdialysis, we demonstrated the existence of a daily rhythm in the output of 5-HT in the SCN of freely behaving hamsters. This rhythm was characterized by a sharp increase in release from a nadir during late midday to peak levels at the light/dark transition. Output declined to basal levels throughout the remainder of the night. A similar pattern also was evident under constant darkness, with increased 5-HT output occurring at the onset of subjective night. Locomotor activity induced by exposure to a novel running wheel had a pronounced phase-dependent effect on 5-HT release in the SCN, with stimulation during the light phase and suppression during the late dark phase. Systemic application of the somatodendritic 5-HT1A agonist BMY 7378 had a significantly greater suppressive effect on 5-HT release in the SCN during the late dark phase compared with mid light phase, indicating that a variation in raphe autoreceptor response may underlie the time-dependent effects of wheel running on 5-HT release. Collectively, these results show that the daily rhythm in output of 5-HT in the SCN is generated endogenously, and that behavioral state can strongly influence serotonergic activity in the circadian clock in a phase-dependent manner." @default.
• W1948200758 created "2016-06-24" @default.
• W1948200758 creator A5047085114 @default.
• W1948200758 creator A5047218665 @default.
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• W1948200758 date "1998-07-01" @default.
• W1948200758 modified "2023-09-24" @default.
• W1948200758 title "Endogenous Regulation of Serotonin Release in the Hamster Suprachiasmatic Nucleus" @default.
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• W1948200758 doi "https://doi.org/10.1523/jneurosci.18-13-05045.1998" @default.
• W1948200758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6792561" @default.
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