FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948266836> ?p ?o ?g. }

• W1948266836 endingPage "119" @default.
• W1948266836 startingPage "91" @default.
• W1948266836 abstract "There is now an abundance of evidence to show that short-chain fatty acids (SCFAs) play an important role in the maintenance of health and the development of disease. SCFAs are a subset of fatty acids that are produced by the gut microbiota during the fermentation of partially and nondigestible polysaccharides. The highest levels of SCFAs are found in the proximal colon, where they are used locally by enterocytes or transported across the gut epithelium into the bloodstream. Two major SCFA signaling mechanisms have been identified, inhibition of histone deacetylases (HDACs) and activation of G-protein-coupled receptors (GPCRs). Since HDACs regulate gene expression, inhibition of HDACs has a vast array of downstream consequences. Our understanding of SCFA-mediated inhibition of HDACs is still in its infancy. GPCRs, particularly GPR43, GPR41, and GPR109A, have been identified as receptors for SCFAs. Studies have implicated a major role for these GPCRs in the regulation of metabolism, inflammation, and disease. SCFAs have been shown to alter chemotaxis and phagocytosis; induce reactive oxygen species (ROS); change cell proliferation and function; have anti-inflammatory, antitumorigenic, and antimicrobial effects; and alter gut integrity. These findings highlight the role of SCFAs as a major player in maintenance of gut and immune homeostasis. Given the vast effects of SCFAs, and that their levels are regulated by diet, they provide a new basis to explain the increased prevalence of inflammatory disease in Westernized countries, as highlighted in this chapter." @default.
• W1948266836 created "2016-06-24" @default.
• W1948266836 creator A5001129167 @default.
• W1948266836 creator A5004140830 @default.
• W1948266836 creator A5019064609 @default.
• W1948266836 creator A5025176757 @default.
• W1948266836 creator A5078499271 @default.
• W1948266836 creator A5082034671 @default.
• W1948266836 date "2014-01-01" @default.
• W1948266836 modified "2023-10-14" @default.
• W1948266836 title "The Role of Short-Chain Fatty Acids in Health and Disease" @default.
• W1948266836 cites W138633729 @default.
• W1948266836 cites W1503425290 @default.
• W1948266836 cites W1506966309 @default.
• W1948266836 cites W1543294787 @default.
• W1948266836 cites W1595488088 @default.
• W1948266836 cites W184020152 @default.
• W1948266836 cites W1934624334 @default.
• W1948266836 cites W1946133036 @default.
• W1948266836 cites W1954014062 @default.
• W1948266836 cites W1963507142 @default.
• W1948266836 cites W1965552561 @default.
• W1948266836 cites W1965985248 @default.
• W1948266836 cites W1969305254 @default.
• W1948266836 cites W1970436192 @default.
• W1948266836 cites W1974968151 @default.
• W1948266836 cites W1975516847 @default.
• W1948266836 cites W1975561334 @default.
• W1948266836 cites W1980459170 @default.
• W1948266836 cites W1982181592 @default.
• W1948266836 cites W1985845937 @default.
• W1948266836 cites W1986350670 @default.
• W1948266836 cites W1988821718 @default.
• W1948266836 cites W1989401022 @default.
• W1948266836 cites W1991074258 @default.
• W1948266836 cites W1992697603 @default.
• W1948266836 cites W1994743002 @default.
• W1948266836 cites W1995297275 @default.
• W1948266836 cites W2000963707 @default.
• W1948266836 cites W2001616480 @default.
• W1948266836 cites W2002633363 @default.
• W1948266836 cites W2002811300 @default.
• W1948266836 cites W2002940994 @default.
• W1948266836 cites W2004118219 @default.
• W1948266836 cites W2005741884 @default.
• W1948266836 cites W2007489219 @default.
• W1948266836 cites W2007655099 @default.
• W1948266836 cites W2013010265 @default.
• W1948266836 cites W2014374346 @default.
• W1948266836 cites W2016216215 @default.
• W1948266836 cites W2016693701 @default.
• W1948266836 cites W2017917348 @default.
• W1948266836 cites W2019567610 @default.
• W1948266836 cites W2021796106 @default.
• W1948266836 cites W2023113611 @default.
• W1948266836 cites W2025192174 @default.
• W1948266836 cites W2026545058 @default.
• W1948266836 cites W2032767323 @default.
• W1948266836 cites W2033079844 @default.
• W1948266836 cites W2034435555 @default.
• W1948266836 cites W2035447755 @default.
• W1948266836 cites W2036547532 @default.
• W1948266836 cites W2038622845 @default.
• W1948266836 cites W2044624774 @default.
• W1948266836 cites W2045119680 @default.
• W1948266836 cites W2047780224 @default.
• W1948266836 cites W2050523021 @default.
• W1948266836 cites W2052516335 @default.
• W1948266836 cites W2056856345 @default.
• W1948266836 cites W2058401170 @default.
• W1948266836 cites W2060915038 @default.
• W1948266836 cites W2062344492 @default.
• W1948266836 cites W2063380767 @default.
• W1948266836 cites W2067938485 @default.
• W1948266836 cites W2071518233 @default.
• W1948266836 cites W2074901682 @default.
• W1948266836 cites W2075053894 @default.
• W1948266836 cites W2076582609 @default.
• W1948266836 cites W2079003739 @default.
• W1948266836 cites W2079536723 @default.
• W1948266836 cites W2082578477 @default.
• W1948266836 cites W2086216523 @default.
• W1948266836 cites W2087292184 @default.
• W1948266836 cites W2089298736 @default.
• W1948266836 cites W2091482921 @default.
• W1948266836 cites W2093756809 @default.
• W1948266836 cites W2097875133 @default.
• W1948266836 cites W2102258628 @default.
• W1948266836 cites W2104742442 @default.
• W1948266836 cites W2105458779 @default.
• W1948266836 cites W2106411106 @default.
• W1948266836 cites W2106993568 @default.
• W1948266836 cites W2109943216 @default.
• W1948266836 cites W2110491379 @default.
• W1948266836 cites W2114452590 @default.
• W1948266836 cites W2115033553 @default.
• W1948266836 cites W2118973303 @default.
• W1948266836 cites W2127906539 @default.

• next