FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948285726> ?p ?o ?g. }

• W1948285726 endingPage "805" @default.
• W1948285726 startingPage "793" @default.
• W1948285726 abstract "Aberrant self-assembly, induced by structural misfolding of the prion proteins, leads to a number of neurodegenerative disorders. In particular, misfolding of the mostly α-helical cellular prion protein (PrP(C)) into a β-sheet-rich disease-causing isoform (PrP(Sc)) is the key molecular event in the formation of PrP(Sc) aggregates. The molecular mechanisms underlying the PrP(C)-to-PrP(Sc) conversion and subsequent aggregation remain to be elucidated. However, in persistently prion-infected cell-culture models, it was shown that treatment with monoclonal antibodies against defined regions of the prion protein (PrP) led to the clearing of PrP(Sc) in cultured cells. To gain more insight into this process, we characterized PrP-antibody complexes in solution using a fast protein liquid chromatography coupled with small-angle x-ray scattering (FPLC-SAXS) procedure. High-quality SAXS data were collected for full-length recombinant mouse PrP [denoted recPrP(23-230)] and N-terminally truncated recPrP(89-230), as well as their complexes with each of two Fab fragments (HuM-P and HuM-R1), which recognize N- and C-terminal epitopes of PrP, respectively. In-line measurements by fast protein liquid chromatography coupled with SAXS minimized data artifacts caused by a non-monodispersed sample, allowing structural analysis of PrP alone and in complex with Fab antibodies. The resulting structural models suggest two mechanisms for how these Fabs may prevent the conversion of PrP(C) into PrP(Sc)." @default.
• W1948285726 created "2016-06-24" @default.
• W1948285726 creator A5000298654 @default.
• W1948285726 creator A5014085090 @default.
• W1948285726 creator A5020529918 @default.
• W1948285726 creator A5023857050 @default.
• W1948285726 creator A5028845140 @default.
• W1948285726 creator A5065689974 @default.
• W1948285726 creator A5066394814 @default.
• W1948285726 creator A5066991343 @default.
• W1948285726 creator A5091107302 @default.
• W1948285726 date "2015-08-01" @default.
• W1948285726 modified "2023-10-18" @default.
• W1948285726 title "Prion Protein—Antibody Complexes Characterized by Chromatography-Coupled Small-Angle X-Ray Scattering" @default.
• W1948285726 cites W1483315850 @default.
• W1948285726 cites W1562017452 @default.
• W1948285726 cites W1591864042 @default.
• W1948285726 cites W1966382960 @default.
• W1948285726 cites W1971487740 @default.
• W1948285726 cites W1972013995 @default.
• W1948285726 cites W1976238793 @default.
• W1948285726 cites W1977038370 @default.
• W1948285726 cites W1978313975 @default.
• W1948285726 cites W1978525961 @default.
• W1948285726 cites W1982126789 @default.
• W1948285726 cites W1999218203 @default.
• W1948285726 cites W2001008407 @default.
• W1948285726 cites W2003918115 @default.
• W1948285726 cites W2007093034 @default.
• W1948285726 cites W2009284411 @default.
• W1948285726 cites W2012778514 @default.
• W1948285726 cites W2013679718 @default.
• W1948285726 cites W2015418077 @default.
• W1948285726 cites W2018816634 @default.
• W1948285726 cites W2022392367 @default.
• W1948285726 cites W2023156380 @default.
• W1948285726 cites W2026072486 @default.
• W1948285726 cites W2031746097 @default.
• W1948285726 cites W2037812629 @default.
• W1948285726 cites W2041867303 @default.
• W1948285726 cites W2042098488 @default.
• W1948285726 cites W2043528001 @default.
• W1948285726 cites W2044250235 @default.
• W1948285726 cites W2045745022 @default.
• W1948285726 cites W2053720630 @default.
• W1948285726 cites W2055121655 @default.
• W1948285726 cites W2057062474 @default.
• W1948285726 cites W2057402939 @default.
• W1948285726 cites W2058519059 @default.
• W1948285726 cites W2058659733 @default.
• W1948285726 cites W2061506539 @default.
• W1948285726 cites W2061603851 @default.
• W1948285726 cites W2061766263 @default.
• W1948285726 cites W2061882511 @default.
• W1948285726 cites W2063062799 @default.
• W1948285726 cites W2063553621 @default.
• W1948285726 cites W2065283382 @default.
• W1948285726 cites W2066088601 @default.
• W1948285726 cites W2066604274 @default.
• W1948285726 cites W2068989592 @default.
• W1948285726 cites W2071178358 @default.
• W1948285726 cites W2072435127 @default.
• W1948285726 cites W2072654958 @default.
• W1948285726 cites W2072731237 @default.
• W1948285726 cites W2079676299 @default.
• W1948285726 cites W2101137168 @default.
• W1948285726 cites W2103226116 @default.
• W1948285726 cites W2117064662 @default.
• W1948285726 cites W2127104838 @default.
• W1948285726 cites W2137212933 @default.
• W1948285726 cites W2138768135 @default.
• W1948285726 cites W2138880839 @default.
• W1948285726 cites W2141970481 @default.
• W1948285726 cites W2142654956 @default.
• W1948285726 cites W2143697213 @default.
• W1948285726 cites W2143795630 @default.
• W1948285726 cites W2144931885 @default.
• W1948285726 cites W2146790448 @default.
• W1948285726 cites W2147554548 @default.
• W1948285726 cites W2148557238 @default.
• W1948285726 cites W2150555206 @default.
• W1948285726 cites W2151460035 @default.
• W1948285726 cites W2152409953 @default.
• W1948285726 cites W2155292205 @default.
• W1948285726 cites W2158999434 @default.
• W1948285726 cites W2167503783 @default.
• W1948285726 cites W2325252308 @default.
• W1948285726 cites W2330060577 @default.
• W1948285726 cites W2769003964 @default.
• W1948285726 cites W4211121722 @default.
• W1948285726 cites W1975464648 @default.
• W1948285726 doi "https://doi.org/10.1016/j.bpj.2015.06.065" @default.
• W1948285726 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4547163" @default.
• W1948285726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26287631" @default.
• W1948285726 hasPublicationYear "2015" @default.
• W1948285726 type Work @default.
• W1948285726 sameAs 1948285726 @default.
• W1948285726 citedByCount "32" @default.

• next