Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948313080> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1948313080 endingPage "1843" @default.
- W1948313080 startingPage "1838" @default.
- W1948313080 abstract "Abstract Background and Aim: The incidence of gallbladder stones is higher in women during pregnancy than in men. Progesterone can inhibit gallbladder motility and facilitate gallstone formation. However, the ionic mechanisms have not been fully illuminated. This study sought to investigate the effects of progesterone on L‐type calcium currents and voltage‐dependent potassium currents in gallbladder smooth muscle cells. Methods: Gallbladder smooth muscle cells were isolated by enzymatic digestion from adult guinea pigs. Ionic currents were recorded by the whole‐cell patch clamp method. Results: Progesterone inhibited L‐type calcium currents in a concentration‐dependent manner. The characteristic of current‐voltage curve was not significantly altered. The amplitude of calcium currents was gradually suppressed, reached a steady‐state level within 4–6 min, and restored partly after washout. In the presence of protein kinase A (PKA) inhibitor, Rp‐cAMP, the inhibitory effect induced by progesterone was apparently attenuated, whereas forskolin, a direct activator of adenylate cyclase, could suppress L‐type calcium channel. However, progesterone did not significantly affect voltage‐dependent potassium currents. Conclusions: Progesterone inhibits L‐type calcium channel by cAMP/PKA pathway in gallbladder smooth muscle cells. This may be an important mechanism for the gallbladder hypomotility induced by progesterone." @default.
- W1948313080 created "2016-06-24" @default.
- W1948313080 creator A5008473320 @default.
- W1948313080 creator A5054685640 @default.
- W1948313080 date "2010-11-23" @default.
- W1948313080 modified "2023-10-16" @default.
- W1948313080 title "Progesterone inhibits L-type calcium currents in gallbladder smooth muscle cells" @default.
- W1948313080 cites W1966262160 @default.
- W1948313080 cites W1970918222 @default.
- W1948313080 cites W1975259854 @default.
- W1948313080 cites W1977181345 @default.
- W1948313080 cites W1984697559 @default.
- W1948313080 cites W1985196243 @default.
- W1948313080 cites W1998434502 @default.
- W1948313080 cites W2010055676 @default.
- W1948313080 cites W2014902951 @default.
- W1948313080 cites W2018635001 @default.
- W1948313080 cites W2033497019 @default.
- W1948313080 cites W2036140289 @default.
- W1948313080 cites W2037763216 @default.
- W1948313080 cites W2049436216 @default.
- W1948313080 cites W2052197270 @default.
- W1948313080 cites W2062291137 @default.
- W1948313080 cites W2078357671 @default.
- W1948313080 cites W2102810548 @default.
- W1948313080 cites W2105503117 @default.
- W1948313080 cites W2114652502 @default.
- W1948313080 cites W2119149016 @default.
- W1948313080 cites W2125060118 @default.
- W1948313080 cites W2128601322 @default.
- W1948313080 cites W2140205166 @default.
- W1948313080 cites W2141697699 @default.
- W1948313080 cites W2160969949 @default.
- W1948313080 cites W2167644938 @default.
- W1948313080 cites W2261634273 @default.
- W1948313080 cites W2289052846 @default.
- W1948313080 cites W2395031936 @default.
- W1948313080 doi "https://doi.org/10.1111/j.1440-1746.2010.06299.x" @default.
- W1948313080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21091994" @default.
- W1948313080 hasPublicationYear "2010" @default.
- W1948313080 type Work @default.
- W1948313080 sameAs 1948313080 @default.
- W1948313080 citedByCount "9" @default.
- W1948313080 countsByYear W19483130802013 @default.
- W1948313080 countsByYear W19483130802014 @default.
- W1948313080 countsByYear W19483130802015 @default.
- W1948313080 countsByYear W19483130802016 @default.
- W1948313080 countsByYear W19483130802017 @default.
- W1948313080 countsByYear W19483130802018 @default.
- W1948313080 countsByYear W19483130802021 @default.
- W1948313080 countsByYear W19483130802022 @default.
- W1948313080 countsByYear W19483130802023 @default.
- W1948313080 crossrefType "journal-article" @default.
- W1948313080 hasAuthorship W1948313080A5008473320 @default.
- W1948313080 hasAuthorship W1948313080A5054685640 @default.
- W1948313080 hasConcept C126322002 @default.
- W1948313080 hasConcept C134018914 @default.
- W1948313080 hasConcept C18699975 @default.
- W1948313080 hasConcept C24998067 @default.
- W1948313080 hasConcept C2777148285 @default.
- W1948313080 hasConcept C2779276759 @default.
- W1948313080 hasConcept C519063684 @default.
- W1948313080 hasConcept C71924100 @default.
- W1948313080 hasConcept C85520022 @default.
- W1948313080 hasConceptScore W1948313080C126322002 @default.
- W1948313080 hasConceptScore W1948313080C134018914 @default.
- W1948313080 hasConceptScore W1948313080C18699975 @default.
- W1948313080 hasConceptScore W1948313080C24998067 @default.
- W1948313080 hasConceptScore W1948313080C2777148285 @default.
- W1948313080 hasConceptScore W1948313080C2779276759 @default.
- W1948313080 hasConceptScore W1948313080C519063684 @default.
- W1948313080 hasConceptScore W1948313080C71924100 @default.
- W1948313080 hasConceptScore W1948313080C85520022 @default.
- W1948313080 hasIssue "12" @default.
- W1948313080 hasLocation W19483130801 @default.
- W1948313080 hasLocation W19483130802 @default.
- W1948313080 hasOpenAccess W1948313080 @default.
- W1948313080 hasPrimaryLocation W19483130801 @default.
- W1948313080 hasRelatedWork W1914122617 @default.
- W1948313080 hasRelatedWork W1983267597 @default.
- W1948313080 hasRelatedWork W1991289683 @default.
- W1948313080 hasRelatedWork W2031844916 @default.
- W1948313080 hasRelatedWork W2055467158 @default.
- W1948313080 hasRelatedWork W2117370894 @default.
- W1948313080 hasRelatedWork W2121293490 @default.
- W1948313080 hasRelatedWork W2164632326 @default.
- W1948313080 hasRelatedWork W2357391547 @default.
- W1948313080 hasRelatedWork W2955355023 @default.
- W1948313080 hasVolume "25" @default.
- W1948313080 isParatext "false" @default.
- W1948313080 isRetracted "false" @default.
- W1948313080 magId "1948313080" @default.
- W1948313080 workType "article" @default.