FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948356799> ?p ?o ?g. }

• W1948356799 abstract "Apoptotic cell death is the leading cause of neuronal loss after neonatal brain injury. Little is known about the intrinsic capacity of the immature cerebral cortex for replacing dead cells. Here we test the hypothesis that neuronal apoptosis is able to trigger compensatory proliferation in surrounding cells. In order to establish a pure apoptotic cell death model and to avoid the confounding effects of broken blood-brain barrier and inflammatory reactions, we used a diphtheria toxin (DT) and diphtheria toxin receptor (DTR) system to induce ablation of layer IV neurons in the rodent somatosensory cortex during the early postnatal period. We found that DT-triggered apoptosis is a slowly progressing event lasting about for 7 days. While dying cells expressed the morphological features of apoptosis, we could not detect immunoreactivity for activated caspase-3 in these cells. Microglia activation and proliferation represented the earliest cellular responses to apoptotic cell death. In addition, we found that induced apoptosis triggered a massive proliferation of undifferentiated progenitor cell pool including Sox2 as well as NG2 cells. The default differentiation pattern of proliferating progenitors appears to be the glial phenotype; we could not find evidence for newly generated neurons in response to apoptotic neuronal death. These results suggest that mitotically active progenitor populations are intrinsically capable to contribute to the repair process of injured cortical tissue and may represent a potential target for neuronal replacement strategies." @default.
• W1948356799 created "2016-06-24" @default.
• W1948356799 creator A5004983468 @default.
• W1948356799 creator A5020862877 @default.
• W1948356799 creator A5060063639 @default.
• W1948356799 creator A5063888708 @default.
• W1948356799 date "2015-11-01" @default.
• W1948356799 modified "2023-09-27" @default.
• W1948356799 title "Apoptotic neurons induce proliferative responses of progenitor cells in the postnatal neocortex" @default.
• W1948356799 cites W1482301804 @default.
• W1948356799 cites W1530155692 @default.
• W1948356799 cites W1570720496 @default.
• W1948356799 cites W1653076540 @default.
• W1948356799 cites W1884746557 @default.
• W1948356799 cites W1901072277 @default.
• W1948356799 cites W1965493535 @default.
• W1948356799 cites W1966744398 @default.
• W1948356799 cites W1971912541 @default.
• W1948356799 cites W1976152949 @default.
• W1948356799 cites W1980789245 @default.
• W1948356799 cites W1981547140 @default.
• W1948356799 cites W1982779457 @default.
• W1948356799 cites W1987169758 @default.
• W1948356799 cites W1991453028 @default.
• W1948356799 cites W1994914496 @default.
• W1948356799 cites W1995291424 @default.
• W1948356799 cites W1999682392 @default.
• W1948356799 cites W2003438784 @default.
• W1948356799 cites W2003644243 @default.
• W1948356799 cites W2003674452 @default.
• W1948356799 cites W2013485257 @default.
• W1948356799 cites W2014277329 @default.
• W1948356799 cites W2017830127 @default.
• W1948356799 cites W2020577322 @default.
• W1948356799 cites W2020577923 @default.
• W1948356799 cites W2021069327 @default.
• W1948356799 cites W2023105628 @default.
• W1948356799 cites W2023936403 @default.
• W1948356799 cites W2025868352 @default.
• W1948356799 cites W2030864103 @default.
• W1948356799 cites W2033617297 @default.
• W1948356799 cites W2033669945 @default.
• W1948356799 cites W2039327710 @default.
• W1948356799 cites W2042141743 @default.
• W1948356799 cites W2044219916 @default.
• W1948356799 cites W2045013955 @default.
• W1948356799 cites W2046637240 @default.
• W1948356799 cites W2049224825 @default.
• W1948356799 cites W2053059756 @default.
• W1948356799 cites W2054119137 @default.
• W1948356799 cites W2055255320 @default.
• W1948356799 cites W2058915525 @default.
• W1948356799 cites W2060062205 @default.
• W1948356799 cites W2064046464 @default.
• W1948356799 cites W2066215889 @default.
• W1948356799 cites W2071763011 @default.
• W1948356799 cites W2074194694 @default.
• W1948356799 cites W2074661552 @default.
• W1948356799 cites W2075317738 @default.
• W1948356799 cites W2083647133 @default.
• W1948356799 cites W2084995170 @default.
• W1948356799 cites W2085921200 @default.
• W1948356799 cites W2090135620 @default.
• W1948356799 cites W2094416985 @default.
• W1948356799 cites W2095490681 @default.
• W1948356799 cites W2100212553 @default.
• W1948356799 cites W2103279601 @default.
• W1948356799 cites W2119913111 @default.
• W1948356799 cites W2126556819 @default.
• W1948356799 cites W2129296504 @default.
• W1948356799 cites W2131934556 @default.
• W1948356799 cites W2133128549 @default.
• W1948356799 cites W2134252550 @default.
• W1948356799 cites W2154745705 @default.
• W1948356799 cites W2163142681 @default.
• W1948356799 cites W2163470859 @default.
• W1948356799 cites W2163964383 @default.
• W1948356799 cites W2165100236 @default.
• W1948356799 cites W2171130969 @default.
• W1948356799 cites W2171374386 @default.
• W1948356799 cites W2460643734 @default.
• W1948356799 doi "https://doi.org/10.1016/j.expneurol.2015.08.010" @default.
• W1948356799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26291762" @default.
• W1948356799 hasPublicationYear "2015" @default.
• W1948356799 type Work @default.
• W1948356799 sameAs 1948356799 @default.
• W1948356799 citedByCount "9" @default.
• W1948356799 countsByYear W19483567992017 @default.
• W1948356799 countsByYear W19483567992018 @default.
• W1948356799 countsByYear W19483567992020 @default.
• W1948356799 crossrefType "journal-article" @default.
• W1948356799 hasAuthorship W1948356799A5004983468 @default.
• W1948356799 hasAuthorship W1948356799A5020862877 @default.
• W1948356799 hasAuthorship W1948356799A5060063639 @default.
• W1948356799 hasAuthorship W1948356799A5063888708 @default.
• W1948356799 hasConcept C136834591 @default.
• W1948356799 hasConcept C15729860 @default.
• W1948356799 hasConcept C169760540 @default.
• W1948356799 hasConcept C190283241 @default.
• W1948356799 hasConcept C201750760 @default.

• next