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- W1948373376 abstract "Orofasial yariklar toplumda ∼1/1000 oraninda gorulmekle birlikte damak ve dudakta beraber bazen de izole olarak gorulmektedirler. Orofasial yariklarin etyolojisinde bir cok faktor rol almaktadir. Ayrica etyolojisi multipl genetik ve cevresel faktorleri icermektedir. Bu patolojinin nadir formlari mendeliyen ve teratojenik orijine sahip multipl konjenital anomaliye sahip sendromlarin bir komponenti olabilir. Herhangi bir sendromun eslik etmedigi izole orofasial yariklar daha sik gorulmekle birlikte etyolojide genelde cevresel faktorler rol oynamaktadir. Genetik biliminde molekuler ve kantitatif olarak meydana gelen gelismeler bu patolojinin sendromik ve sendromik olmayan her iki tipinde de genetik mekanizmalarinin rol oynuyor olabilecegini dusundurmektedir. Hayvan modellerinde yapilan calismalarda bu patolojinin etyolojisine isik tutmaya calismaktadir. Biz bu derlememizle orofasial yarik iceren insan ve hayvan modellerinde genetik faktorleri degerlendirmek ve genetik ile cevresel faktorlerin birbiriyle iliskisini belirlemeyi amacladik." @default.
- W1948373376 created "2016-06-24" @default.
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- W1948373376 date "2014-01-06" @default.
- W1948373376 modified "2023-09-26" @default.
- W1948373376 title "Congenital orofacial clefts: Etiology and Frequency" @default.
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- W1948373376 doi "https://doi.org/10.5798/diclemedj.0921.2014.02.0447" @default.
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