Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948376788> ?p ?o ?g. }
- W1948376788 endingPage "113" @default.
- W1948376788 startingPage "89" @default.
- W1948376788 abstract "Smac/DIABLO, discovered in 2000 as a protein released from mitochondria into the cytosol in response to apoptotic stimuli, functions as an endogenous antagonist of X-linked inhibitor of apoptosis protein (XIAP) and several other IAP proteins through direct binding. The interaction between Smac and IAPs involves the AVPI tetrapeptide binding motif on the N-terminus of Smac and a well-defined groove on the surface of these IAP proteins, providing an ideal site for the design of small-molecule Smac mimetics. Potent and cell-permeable small-molecule Smac mimetics have provided powerful pharmacological tools for study of the regulation of apoptosis by IAP proteins, and several such compounds are now in early clinical trials as new anticancer agents." @default.
- W1948376788 created "2016-06-24" @default.
- W1948376788 creator A5073754378 @default.
- W1948376788 date "2010-01-01" @default.
- W1948376788 modified "2023-10-02" @default.
- W1948376788 title "Design of Small-Molecule Smac Mimetics as IAP Antagonists" @default.
- W1948376788 cites W1492587973 @default.
- W1948376788 cites W1616649922 @default.
- W1948376788 cites W1618299283 @default.
- W1948376788 cites W1976353819 @default.
- W1948376788 cites W1976935037 @default.
- W1948376788 cites W1986320887 @default.
- W1948376788 cites W1989277510 @default.
- W1948376788 cites W1993262772 @default.
- W1948376788 cites W1993470980 @default.
- W1948376788 cites W1998423564 @default.
- W1948376788 cites W2003926188 @default.
- W1948376788 cites W2004611844 @default.
- W1948376788 cites W2005572311 @default.
- W1948376788 cites W2008443832 @default.
- W1948376788 cites W2008842667 @default.
- W1948376788 cites W2014569891 @default.
- W1948376788 cites W2035493275 @default.
- W1948376788 cites W2039597975 @default.
- W1948376788 cites W2040370168 @default.
- W1948376788 cites W2042409437 @default.
- W1948376788 cites W2043817378 @default.
- W1948376788 cites W2046836366 @default.
- W1948376788 cites W2048593328 @default.
- W1948376788 cites W2053308358 @default.
- W1948376788 cites W2053550021 @default.
- W1948376788 cites W2054717287 @default.
- W1948376788 cites W2064299413 @default.
- W1948376788 cites W2065818103 @default.
- W1948376788 cites W2069766232 @default.
- W1948376788 cites W2069800916 @default.
- W1948376788 cites W2080207536 @default.
- W1948376788 cites W2080916979 @default.
- W1948376788 cites W2086329655 @default.
- W1948376788 cites W2093475144 @default.
- W1948376788 cites W2093556522 @default.
- W1948376788 cites W2097644162 @default.
- W1948376788 cites W2101023638 @default.
- W1948376788 cites W2101243737 @default.
- W1948376788 cites W2116609506 @default.
- W1948376788 cites W2123513769 @default.
- W1948376788 cites W2125715557 @default.
- W1948376788 cites W2134452061 @default.
- W1948376788 cites W2139059024 @default.
- W1948376788 cites W2144841919 @default.
- W1948376788 cites W2145006562 @default.
- W1948376788 cites W2160029849 @default.
- W1948376788 cites W2162653594 @default.
- W1948376788 cites W2165566753 @default.
- W1948376788 cites W2167490100 @default.
- W1948376788 cites W2170507464 @default.
- W1948376788 cites W4235457469 @default.
- W1948376788 cites W4355260 @default.
- W1948376788 doi "https://doi.org/10.1007/82_2010_111" @default.
- W1948376788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21072626" @default.
- W1948376788 hasPublicationYear "2010" @default.
- W1948376788 type Work @default.
- W1948376788 sameAs 1948376788 @default.
- W1948376788 citedByCount "32" @default.
- W1948376788 countsByYear W19483767882012 @default.
- W1948376788 countsByYear W19483767882013 @default.
- W1948376788 countsByYear W19483767882014 @default.
- W1948376788 countsByYear W19483767882015 @default.
- W1948376788 countsByYear W19483767882016 @default.
- W1948376788 countsByYear W19483767882017 @default.
- W1948376788 countsByYear W19483767882018 @default.
- W1948376788 countsByYear W19483767882019 @default.
- W1948376788 countsByYear W19483767882020 @default.
- W1948376788 countsByYear W19483767882022 @default.
- W1948376788 countsByYear W19483767882023 @default.
- W1948376788 crossrefType "book-chapter" @default.
- W1948376788 hasAuthorship W1948376788A5073754378 @default.
- W1948376788 hasConcept C107824862 @default.
- W1948376788 hasConcept C161624437 @default.
- W1948376788 hasConcept C181199279 @default.
- W1948376788 hasConcept C185592680 @default.
- W1948376788 hasConcept C190283241 @default.
- W1948376788 hasConcept C2777408456 @default.
- W1948376788 hasConcept C2779281246 @default.
- W1948376788 hasConcept C2779564779 @default.
- W1948376788 hasConcept C31573885 @default.
- W1948376788 hasConcept C33195913 @default.
- W1948376788 hasConcept C55493867 @default.
- W1948376788 hasConcept C86803240 @default.
- W1948376788 hasConcept C95444343 @default.
- W1948376788 hasConcept C98424977 @default.
- W1948376788 hasConcept C98539663 @default.
- W1948376788 hasConceptScore W1948376788C107824862 @default.
- W1948376788 hasConceptScore W1948376788C161624437 @default.
- W1948376788 hasConceptScore W1948376788C181199279 @default.
- W1948376788 hasConceptScore W1948376788C185592680 @default.
- W1948376788 hasConceptScore W1948376788C190283241 @default.
- W1948376788 hasConceptScore W1948376788C2777408456 @default.