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- W194855170 abstract "Abstract 4-15% of cystic fibrosis (CF) patients develop Allergic Bronchopulmonary Aspergillosis (ABPA) characterized by heightened Th2 responses to Aspergillus fumigatus (Af). Colonization rates with Af in CF can approach 40-50% suggesting immune tolerance may prevent ABPA. We have previously shown that CD11c dendritic cells (DCs), OX40 Ligand, Vitamin D play a role in sensitization versus tolerance to Af in CF patients. We have set up an animal model to further explore the roles of CD11c DCs, OX40L, and Vitamin D in response to Af. Vitamin D deficient mice (by nutritional diet) and Vitamin D normal mice where sensitized and challenged with Af. In addition, mice were given anti-OX40L or PBS control 4 hours prior to Af challenge. Lung, lymph nodes (LN), and bronchoalveolar lavage (BAL) fluid where analyzed for Th2 cytokine production. Vitamin D deficient mice have significantly increased Th2 cytokine response to Af in lung, BAL, and LN. In addition, OX40L mRNA levels are increased in Vitamin D deficient mice compared to Vitamin D normal mice. When given anti-OX40L prior to Af challenge, Th2 response in both Vitamin D deficient and Vitamin D normal mice are attenuated confirming the critical role of OX40L driven Th2 response in Af sensitization. This suggests a critical role of OX40L in Vitamin D mediated Th2 suppression. These results support therapeutic trial of Vitamin D and/or anti-OX40L to treat ABPA in CF and suggest Vitamin D plays a role in immune tolerance to Af." @default.
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- W194855170 date "2012-05-01" @default.
- W194855170 modified "2023-10-16" @default.
- W194855170 title "Vitamin D regulation of Th2 Immune responses to Aspergillus fumigatus in mice and humans: role of OX40L (164.19)" @default.
- W194855170 doi "https://doi.org/10.4049/jimmunol.188.supp.164.19" @default.
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