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• W1948558382 abstract "Aminobisphosphonates, potent derivatives of bisphosphonates, are frequently used for the treatment of conditions such as osteoporosis and bone metastases that are characterized by excessive osteoclastic bone resorption. Using T-cell receptor (TCR) transfer studies, we show that recognition of antigenic aminobisphosphonates that are known to stimulate human γδ T cells in vitro and in vivo (potency: risedronate &gt; alendronate &gt; pamidronate) requires expression of the Vγ2Vδ2 TCR and is thus Vγ2Vδ2 TCR–dependent. Myeloma cells or monocytes pulsed with risedronate and then washed rendered these target cells sensitive to lysis by a Vγ2Vδ2 T-cell clone or cell line. These results suggest that Vγ2Vδ2 TCR–dependent recognition leading to direct cytolysis of aminobisphosphonate-sensitized osteoclast or tumor targets may be a mechanism whereby aminobisphosphonate treatment of cancers metastatic to bone decreases osteoclastic activity and tumor burden and also may account for the decreased osteoclastic activity associated with successful treatment of osteoporosis." @default.
• W1948558382 created "2016-06-24" @default.
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• W1948558382 date "2001-09-01" @default.
• W1948558382 modified "2023-09-30" @default.
• W1948558382 title "Vγ2Vδ2 T-cell receptor–mediated recognition of aminobisphosphonates" @default.
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• W1948558382 doi "https://doi.org/10.1182/blood.v98.5.1616" @default.
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