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- W1948567422 abstract "Abstract Aim We created a new reference standard focusing on the hemispheric anteroposterior cerebellar diameter (APCD) in addition to the transverse cerebellar diameter (TCD) and discussed whether or not the cerebellar measurement was useful for the detection of trisomy 18 (T18). Material and Methods In 150 normal fetuses between 14 and 36 weeks of gestational age (GA), the TCD and APCD were prospectively measured. In 26 cases with T18, the value was compared with the control. Results At <22 weeks of gestation, the TCD reference standard was calculated as follows: TCD = (1.027 × GA) – 0.674 (R 2 = 0.97, P < 0.001). The reference standard of the APCD was calculated as follows: APCD = (0.682 × GA) – 3.925 (R 2 = 0.73, P < 0.001). In eight cases with T18, the TCD was below the 5th percentile value in 7/8 (88%) cases and the APCD was below the 5th percentile value in 8/8 (100%) cases. At >22 weeks of gestation, the reference standard of the TCD was calculated as follows: TCD = (1.603 × GA) – 13.216 (R 2 = 0.92, P < 0.001). The reference standard of the APCD was calculated as follows: APCD = (0.859 × GA) – 7.30 (R 2 = 0.84, P < 0.001). In 18 cases with T18, the TCD was below the 5th percentile value in 14/18 (78%) cases and the APCD was below the 5th percentile value in 18/18 (100%) cases. Conclusion APCD reference standard, divided by the gestational age of more or less than 22 weeks, might be useful to diagnose T18." @default.
- W1948567422 created "2016-06-24" @default.
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- W1948567422 date "2015-08-26" @default.
- W1948567422 modified "2023-10-03" @default.
- W1948567422 title "Creation of a cerebellar diameter reference standard and its clinical application to the detection of cerebellar hypoplasia unique to trisomy 18" @default.
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- W1948567422 doi "https://doi.org/10.1111/jog.12814" @default.
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