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• W1948614900 abstract "Solubilization of opioid receptors from rat cortical membranes that retained high-affinity guanine nucleotide-sensitive agonist binding was achieved using 10 mM CHAPS. We report the nature of the interactions of mu and delta opioid receptors with the guanine nucleotide-binding protein G(o) by immunoprecipitation of CHAPS extracts with selective G(o)alpha-subunit protein antisera. Antiserum IM1 raised against amino acids 22-35 of G(o)alpha selectively co-immunoprecipitated G(o)alpha-mu and G(o)alpha-delta opioid receptor complexes detected in the immunoprecipitates by specific [3H][D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin and [3H][D-Ser2,Leu5,Thr6]enkephalin binding respectively. By contrast, antisera directed against the C-terminal decapeptide (OC2) and the N-terminal hexadecapeptide (ON1) of isoforms of G(o)alpha were unable to immunoprecipitate solubilized opioid receptor-G(o) complexes, although both were able to immunoprecipitate solubilized G(o)alpha and have been shown to reduce the affinity of [D-Ala2,D-Leu5]enkephalin for opioid receptors in rat cortical membranes [Georgoussi, Carr and Milligan (1993) Mol. Pharmacol. 44, 62-69]. These findings demonstrate that CHAPS-solubilized mu and delta opioid receptors from rat cortical membranes form stable complexes with one or more variants of G(o)." @default.
• W1948614900 created "2016-06-24" @default.
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• W1948614900 creator A5051585961 @default.
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• W1948614900 date "1995-02-15" @default.
• W1948614900 modified "2023-10-01" @default.
• W1948614900 title "Immunoprecipitation of opioid receptor-Go-protein complexes using specific GTP-binding-protein antisera" @default.
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• W1948614900 doi "https://doi.org/10.1042/bj3060071" @default.
• W1948614900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1136483" @default.
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