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- W1948626122 abstract "LCI is a robust measure of ventilation distribution in CF. There are no data demonstrating a relationship between LCI and biomarkers of systemic inflammation during clinical stability. Objective : To investigate the relationship between C-reactive protein, (CRP), White Cell Count (WCC) and LCI in CF. Methods : Stable CF patients from Northern Ireland CF centres, aged ≥ 6 years were recruited. LCI was derived from multiple breath washout. Blood CRP and WCC were measured by turbidimetric immunoassay. Spearman correlation coefficient was used. Results: n=83 (table 1). CRP (figure 1) and WCC (figure 2) had a significant correlation with LCI. Similarly, there was a significant correlation between CRP (r=-0.37; p=0.0006),WCC (r=-0.47; p 1 % pred. Conclusion: Increased systemic inflammation in CF is associated with deterioration in LCI. Funder: US-Ireland Project Partnership Grant." @default.
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- W1948626122 date "2014-09-01" @default.
- W1948626122 modified "2023-09-27" @default.
- W1948626122 title "Increased systemic inflammation in cystic fibrosis (CF) is associated with deterioration in lung clearance index (LCI)" @default.
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