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- W194865385 abstract "The evaluation of anti-neoplastic agents in the treatment of patients with carcinoma of the adrenal cortex has been relatively limited since the incidence of this tumor is only 0.2/100,000. However, the propensity for adrenal cortical carcinoma to excrete hormones has led to unique groups of drugs which produce significant palliation of bothersome and life-threatening endocrinologically induced symptoms. Cushing’s syndrome, virilization, feminization, sexual precocity, gynecomastia, hirsutism and hypertension, which are more frequently recognized in females and young children, are secondary to the overproduction of various class II (glucocorticoid) and III (17-ketosteroid) steroids. Malignant adrenal cell carcinoma, which is of mesodermal origin, does not excrete ‘unusual steroids’, rather they simply ‘reflect inefficient use of the normal steroid precursors by the neoplasm and increased excretion of the metabolites normally present in only trace amounts’ (Lipsett et al. 1963). For example, it has been estimated that the excretion rate of 17-hydroxycorticoids (17-OH) averages 1 mg/g of normal adrenal tissue compared to only 0.1-0.2 mg/g of tumor (Lipsett et al. 1963). In addition, such tumors are not totally independent of normal hormonal control since some investigators have found modulation of steroid secretion with ACTH (adrenocorticotropin and dexamethasone administration (Rayfield et al. 1971; Bulger and Correa 1977). Thus, a large tumor burden is generally required before significant endocrinologic signs and symptoms appear which is in marked contrast to the efficient steroid production by small non-malignant adrenal cortical adenomas." @default.
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- W194865385 date "1982-01-01" @default.
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- W194865385 title "Chemotherapy of Adrenal Cortical Carcinoma" @default.
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- W194865385 doi "https://doi.org/10.1007/978-1-4471-1332-4_1" @default.
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