Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948654792> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1948654792 endingPage "530" @default.
- W1948654792 startingPage "526" @default.
- W1948654792 abstract "Moxifloxacin is characterized by high activity against Gram-positive cocci and some Gram-positive and -negative anaerobes, including Clostridium difficile. This study investigates the role of prior quinolone use in relation to patterns of susceptibility of C. difficile to moxifloxacin.Sixty-three clinical isolates of C. difficile were investigated for toxigenicity, susceptibility to moxifloxacin, and mutations in the DNA gyrase gene. The medical histories for 50 of these patients were available and used to identify previous fluoroquinolone use.Thirty-three (52.4%) strains showed resistance to moxifloxacin (MICs > or = 16 mg/L). All moxifloxacin-resistant strains harbored a mutation at amino acid codon Ser-83 of gyrA. Forty-five isolates (71.4%) were toxigenic; all moxifloxacin-resistant strains were in this group. Resistance to moxifloxacin was associated with prior use of fluoroquinolones (P-value 0.009, chi-square).Although the use of moxifloxacin to treat C. difficile-associated diarrhea is not likely to be common, these data show a relationship between antecedent fluoroquinolone use and resistance to moxifloxacin in C. difficile isolates, and raise questions regarding selection pressure for resistance placed on colonizing bacteria exposed to fluoroquinolones. Mutations in gyrA are involved in moxifloxacin resistance." @default.
- W1948654792 created "2016-06-24" @default.
- W1948654792 creator A5006041032 @default.
- W1948654792 creator A5017888308 @default.
- W1948654792 creator A5029671726 @default.
- W1948654792 creator A5058036692 @default.
- W1948654792 creator A5061001455 @default.
- W1948654792 creator A5067095683 @default.
- W1948654792 creator A5070787737 @default.
- W1948654792 date "2003-06-01" @default.
- W1948654792 modified "2023-09-27" @default.
- W1948654792 title "Antecedent use of fluoroquinolones is associated with resistance to moxifloxacin in Clostridium difficile" @default.
- W1948654792 cites W1935895845 @default.
- W1948654792 cites W1967295727 @default.
- W1948654792 cites W2073339113 @default.
- W1948654792 cites W2081417349 @default.
- W1948654792 cites W2095941723 @default.
- W1948654792 cites W2098533214 @default.
- W1948654792 cites W2099125976 @default.
- W1948654792 cites W2100641815 @default.
- W1948654792 cites W2110132014 @default.
- W1948654792 cites W2131305379 @default.
- W1948654792 cites W2142025154 @default.
- W1948654792 cites W2158023121 @default.
- W1948654792 cites W2160194059 @default.
- W1948654792 cites W2162981315 @default.
- W1948654792 cites W2166818838 @default.
- W1948654792 cites W2318911370 @default.
- W1948654792 doi "https://doi.org/10.1046/j.1469-0691.2003.00559.x" @default.
- W1948654792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12848728" @default.
- W1948654792 hasPublicationYear "2003" @default.
- W1948654792 type Work @default.
- W1948654792 sameAs 1948654792 @default.
- W1948654792 citedByCount "44" @default.
- W1948654792 countsByYear W19486547922012 @default.
- W1948654792 countsByYear W19486547922014 @default.
- W1948654792 countsByYear W19486547922015 @default.
- W1948654792 countsByYear W19486547922017 @default.
- W1948654792 countsByYear W19486547922018 @default.
- W1948654792 countsByYear W19486547922019 @default.
- W1948654792 countsByYear W19486547922021 @default.
- W1948654792 countsByYear W19486547922022 @default.
- W1948654792 countsByYear W19486547922023 @default.
- W1948654792 crossrefType "journal-article" @default.
- W1948654792 hasAuthorship W1948654792A5006041032 @default.
- W1948654792 hasAuthorship W1948654792A5017888308 @default.
- W1948654792 hasAuthorship W1948654792A5029671726 @default.
- W1948654792 hasAuthorship W1948654792A5058036692 @default.
- W1948654792 hasAuthorship W1948654792A5061001455 @default.
- W1948654792 hasAuthorship W1948654792A5067095683 @default.
- W1948654792 hasAuthorship W1948654792A5070787737 @default.
- W1948654792 hasBestOaLocation W19486547921 @default.
- W1948654792 hasConcept C104317684 @default.
- W1948654792 hasConcept C167125095 @default.
- W1948654792 hasConcept C2778836808 @default.
- W1948654792 hasConcept C2781276175 @default.
- W1948654792 hasConcept C2994496256 @default.
- W1948654792 hasConcept C501593827 @default.
- W1948654792 hasConcept C54355233 @default.
- W1948654792 hasConcept C547475151 @default.
- W1948654792 hasConcept C71924100 @default.
- W1948654792 hasConcept C86803240 @default.
- W1948654792 hasConcept C89423630 @default.
- W1948654792 hasConceptScore W1948654792C104317684 @default.
- W1948654792 hasConceptScore W1948654792C167125095 @default.
- W1948654792 hasConceptScore W1948654792C2778836808 @default.
- W1948654792 hasConceptScore W1948654792C2781276175 @default.
- W1948654792 hasConceptScore W1948654792C2994496256 @default.
- W1948654792 hasConceptScore W1948654792C501593827 @default.
- W1948654792 hasConceptScore W1948654792C54355233 @default.
- W1948654792 hasConceptScore W1948654792C547475151 @default.
- W1948654792 hasConceptScore W1948654792C71924100 @default.
- W1948654792 hasConceptScore W1948654792C86803240 @default.
- W1948654792 hasConceptScore W1948654792C89423630 @default.
- W1948654792 hasIssue "6" @default.
- W1948654792 hasLocation W19486547921 @default.
- W1948654792 hasLocation W19486547922 @default.
- W1948654792 hasOpenAccess W1948654792 @default.
- W1948654792 hasPrimaryLocation W19486547921 @default.
- W1948654792 hasRelatedWork W1948654792 @default.
- W1948654792 hasRelatedWork W2095941723 @default.
- W1948654792 hasRelatedWork W2106831385 @default.
- W1948654792 hasRelatedWork W2124395666 @default.
- W1948654792 hasRelatedWork W2125087041 @default.
- W1948654792 hasRelatedWork W2136643094 @default.
- W1948654792 hasRelatedWork W2147917069 @default.
- W1948654792 hasRelatedWork W2383949983 @default.
- W1948654792 hasRelatedWork W3102761612 @default.
- W1948654792 hasRelatedWork W4221047151 @default.
- W1948654792 hasVolume "9" @default.
- W1948654792 isParatext "false" @default.
- W1948654792 isRetracted "false" @default.
- W1948654792 magId "1948654792" @default.
- W1948654792 workType "article" @default.