Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948736584> ?p ?o ?g. }
- W1948736584 endingPage "9584" @default.
- W1948736584 startingPage "9572" @default.
- W1948736584 abstract "To explore novel roles of glial cells in synaptic function and formation, we examined the expression of agrin in frog Schwann cells and tested their role in the aggregation of acetylcholine receptors (AChRs). Using reverse transcription-PCR, we found that Schwann cells along nerve fibers in tadpoles expressed only the inactive agrin isoform B0 but began to also express active agrin isoforms B11 and B19 at approximately metamorphosis. During nerve regeneration in the adult, the expression of these active agrin isoforms in Schwann cells was upregulated, including the appearance of the most potent isoform, B8. This upregulation was induced by regenerating axons but not by nerve injury per se. In muscle cultures, the presence of adult Schwann cells enhanced the number and the total area of AChR aggregates 2.2- and 4.5-fold, respectively, and this enhancement was eliminated by heparin treatment. Furthermore, adult Schwann cells in culture expressed active agrin isoforms and produced agrin protein. Using a novel technique to selectively ablate perisynaptic Schwann cells (PSCs) at the neuromuscular junction, we found that PSCs also expressed active agrin isoforms B11 and B19, and these active isoforms were upregulated, including the appearance of B8, during reinnervation. Observation in vivo showed that extrajunctional AChR aggregates were associated with PSC sprouts after nerve injury and subsequent reinnervation. These results suggest that, contrary to the prevailing view that only neurons express active agrin, glial cells also express active agrin and play a role in the aggregation of AChRs both in vitro and in vivo." @default.
- W1948736584 created "2016-06-24" @default.
- W1948736584 creator A5003431034 @default.
- W1948736584 creator A5008996578 @default.
- W1948736584 creator A5011478998 @default.
- W1948736584 creator A5028181567 @default.
- W1948736584 creator A5075085688 @default.
- W1948736584 date "2001-12-15" @default.
- W1948736584 modified "2023-09-23" @default.
- W1948736584 title "Schwann Cells Express Active Agrin and Enhance Aggregation of Acetylcholine Receptors on Muscle Fibers" @default.
- W1948736584 cites W1579118721 @default.
- W1948736584 cites W1593191787 @default.
- W1948736584 cites W1598768057 @default.
- W1948736584 cites W1646176800 @default.
- W1948736584 cites W1718658880 @default.
- W1948736584 cites W1869842964 @default.
- W1948736584 cites W1909813921 @default.
- W1948736584 cites W1973145918 @default.
- W1948736584 cites W1973677292 @default.
- W1948736584 cites W1985946266 @default.
- W1948736584 cites W1988982176 @default.
- W1948736584 cites W1994980684 @default.
- W1948736584 cites W1996050430 @default.
- W1948736584 cites W1998116879 @default.
- W1948736584 cites W1999880438 @default.
- W1948736584 cites W2000314545 @default.
- W1948736584 cites W2002156001 @default.
- W1948736584 cites W2009720902 @default.
- W1948736584 cites W2021732143 @default.
- W1948736584 cites W2023479137 @default.
- W1948736584 cites W2024523695 @default.
- W1948736584 cites W2027397345 @default.
- W1948736584 cites W2030291352 @default.
- W1948736584 cites W2031435436 @default.
- W1948736584 cites W2034899304 @default.
- W1948736584 cites W2043259162 @default.
- W1948736584 cites W2044730840 @default.
- W1948736584 cites W2046678465 @default.
- W1948736584 cites W2047428077 @default.
- W1948736584 cites W2048421444 @default.
- W1948736584 cites W2058698951 @default.
- W1948736584 cites W2068435529 @default.
- W1948736584 cites W2081532398 @default.
- W1948736584 cites W2084943582 @default.
- W1948736584 cites W2089011655 @default.
- W1948736584 cites W2090390636 @default.
- W1948736584 cites W2090473949 @default.
- W1948736584 cites W2094689830 @default.
- W1948736584 cites W2113222929 @default.
- W1948736584 cites W2122937190 @default.
- W1948736584 cites W2134505400 @default.
- W1948736584 cites W2155080404 @default.
- W1948736584 cites W2164350848 @default.
- W1948736584 cites W2165356341 @default.
- W1948736584 cites W291930200 @default.
- W1948736584 doi "https://doi.org/10.1523/jneurosci.21-24-09572.2001" @default.
- W1948736584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6763019" @default.
- W1948736584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11739568" @default.
- W1948736584 hasPublicationYear "2001" @default.
- W1948736584 type Work @default.
- W1948736584 sameAs 1948736584 @default.
- W1948736584 citedByCount "71" @default.
- W1948736584 countsByYear W19487365842012 @default.
- W1948736584 countsByYear W19487365842014 @default.
- W1948736584 countsByYear W19487365842015 @default.
- W1948736584 countsByYear W19487365842016 @default.
- W1948736584 countsByYear W19487365842017 @default.
- W1948736584 countsByYear W19487365842018 @default.
- W1948736584 countsByYear W19487365842019 @default.
- W1948736584 countsByYear W19487365842020 @default.
- W1948736584 countsByYear W19487365842021 @default.
- W1948736584 countsByYear W19487365842022 @default.
- W1948736584 countsByYear W19487365842023 @default.
- W1948736584 crossrefType "journal-article" @default.
- W1948736584 hasAuthorship W1948736584A5003431034 @default.
- W1948736584 hasAuthorship W1948736584A5008996578 @default.
- W1948736584 hasAuthorship W1948736584A5011478998 @default.
- W1948736584 hasAuthorship W1948736584A5028181567 @default.
- W1948736584 hasAuthorship W1948736584A5075085688 @default.
- W1948736584 hasBestOaLocation W19487365841 @default.
- W1948736584 hasConcept C104317684 @default.
- W1948736584 hasConcept C127561419 @default.
- W1948736584 hasConcept C169760540 @default.
- W1948736584 hasConcept C170493617 @default.
- W1948736584 hasConcept C185323287 @default.
- W1948736584 hasConcept C185592680 @default.
- W1948736584 hasConcept C2777004073 @default.
- W1948736584 hasConcept C2777240379 @default.
- W1948736584 hasConcept C2779024559 @default.
- W1948736584 hasConcept C2779649809 @default.
- W1948736584 hasConcept C53345823 @default.
- W1948736584 hasConcept C55493867 @default.
- W1948736584 hasConcept C62478195 @default.
- W1948736584 hasConcept C80161118 @default.
- W1948736584 hasConcept C86803240 @default.
- W1948736584 hasConcept C95444343 @default.
- W1948736584 hasConceptScore W1948736584C104317684 @default.
- W1948736584 hasConceptScore W1948736584C127561419 @default.